Anatomical Pathology research

The Department of Anatomical Pathology’s main research areas involve collaborative projects on breast cancer, liver cancer, prostate cancer, melanoma, muscle disease and neurodegenerative diseases.

Grants

Professor McLean is a co-investigator on the Victorian Cancer Agency Melbourne Melanoma Project Award (2014- 2017), of over $3 million, led by Professor Grant McArthur of Peter MacCallum Cancer Centre. The Victorian Melanoma Service is also a co-investigator on this project.

In collaboration with her Monash University partner Professor Christina Mitchell, Professor Catriona MacLean was awarded:

  • A five-year NHMRC Project Grant (2015-2019) of $916,231 entitled ‘Characterisation of autophagy deficiency in skeletal muscle homeostasis’ (CIA: Mitchell; CIC: McLean).
  • A 12-month Cancer Council Victoria Grant-in-Aid for 2015 of $100,000 entitled ‘Characterisation of a novel oncogenic pathway in breast cancer’ (CIA: Mitchell; CIB: McLean). Studies will be aimed at looking at both primary and secondary tumour growth.

Prizes

In 2014, trainee Dr Louise Jackett and Professor McLean were awarded first prize at the National Update in Pathology (a Royal College of Pathologists of Australia meeting) for their work on ‘Correlation of autopsy pathology with clinical diagnoses in life’. Appreciating the diagnoses that are missed provides an important contribution to improving clinical practice at Alfred Health.

Publications

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Lothian A, Lago L, Mukherjee S, Connor AR, Fowler C, McLean CA, Horne M, Masters CL, Cappai R, Roberts BR

(2019), Metallomics, 11(1), 128-40

DOI: 10.1039/c8mt00223a

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

Grubman A, Chew G, Ouyang JF, Sun G, Choo XY, McLean C, Simmons RK, Buckberry S, Vargas-Landin DB, Poppe D, Pflueger J, Lister R, Rackham OJL, Petretto E, Polo JM

(2019), Nat Neurosci, 22(12), 2087-97

DOI: 10.1038/s41593-019-0539-4

Artificial stone-associated silicosis: clinical-pathological-radiological correlates of disease

Levin K, McLean C, Hoy R

(2019), Respirology Case Reports, 7(7), e00470

DOI: 10.1002/rcr2.470

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