Anatomical Pathology research

The Department of Anatomical Pathology’s main research areas involve collaborative projects on breast cancer, liver cancer, prostate cancer, melanoma, muscle disease and neurodegenerative diseases.

Grants

Professor McLean is a co-investigator on the Victorian Cancer Agency Melbourne Melanoma Project Award (2014- 2017), of over $3 million, led by Professor Grant McArthur of Peter MacCallum Cancer Centre. The Victorian Melanoma Service is also a co-investigator on this project.

In collaboration with her Monash University partner Professor Christina Mitchell, Professor Catriona MacLean was awarded:

  • A five-year NHMRC Project Grant (2015-2019) of $916,231 entitled ‘Characterisation of autophagy deficiency in skeletal muscle homeostasis’ (CIA: Mitchell; CIC: McLean).
  • A 12-month Cancer Council Victoria Grant-in-Aid for 2015 of $100,000 entitled ‘Characterisation of a novel oncogenic pathway in breast cancer’ (CIA: Mitchell; CIB: McLean). Studies will be aimed at looking at both primary and secondary tumour growth.

Prizes

In 2014, trainee Dr Louise Jackett and Professor McLean were awarded first prize at the National Update in Pathology (a Royal College of Pathologists of Australia meeting) for their work on ‘Correlation of autopsy pathology with clinical diagnoses in life’. Appreciating the diagnoses that are missed provides an important contribution to improving clinical practice at Alfred Health.

Publications

Wound healing after cultured epithelial autografting in patients with massive burn injury: A cohort study

Lo CH, Akbarzadeh S, McLean C, Ives A, Paul E, Brown WA, Cleland H

(2019), J PLAST RECONSTR AES, 72(3), 42737

DOI: 10.1016/j.bjps.2018.11.003

Importance of muscle biopsy to establish pathogenicity of DMD missense and splice variants

Jones HF, Bryen SJ, Waddell LB, Bournazos A, Davis M, Farrar MA, McLean CA, Mowat DR, Sampaio H, Woodcock IR, Ryan MM, Jones KJ, Cooper ST

(2019), NEUROMUSCULAR DISORD, 29(12), 913-9

DOI: 10.1016/j.nmd.2019.09.013

Improving diagnostic accuracy for suspicious melanocytic skin lesions: New Australian melanoma clinical practice guidelines stress the importance of clinician/pathologist communication

Scolyer RA, Soyer HP, Kelly JW, James C, McLean CA, Coventry BJ, Ferguson PM, Rawson RV, Mar VJ, de Menezes SL, Fishburn P, Stretch JR, Lee S, Thompson JF

(2019), Aust J Gen Pract, 48(6), 357-62

DOI: 10.31128/AJGP-11-18-4759

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