Anatomical Pathology research

The Department of Anatomical Pathology’s main research areas involve collaborative projects on breast cancer, liver cancer, prostate cancer, melanoma, muscle disease and neurodegenerative diseases.

Grants

Professor McLean is a co-investigator on the Victorian Cancer Agency Melbourne Melanoma Project Award (2014- 2017), of over $3 million, led by Professor Grant McArthur of Peter MacCallum Cancer Centre. The Victorian Melanoma Service is also a co-investigator on this project.

In collaboration with her Monash University partner Professor Christina Mitchell, Professor Catriona MacLean was awarded:

  • A five-year NHMRC Project Grant (2015-2019) of $916,231 entitled ‘Characterisation of autophagy deficiency in skeletal muscle homeostasis’ (CIA: Mitchell; CIC: McLean).
  • A 12-month Cancer Council Victoria Grant-in-Aid for 2015 of $100,000 entitled ‘Characterisation of a novel oncogenic pathway in breast cancer’ (CIA: Mitchell; CIB: McLean). Studies will be aimed at looking at both primary and secondary tumour growth.

Prizes

In 2014, trainee Dr Louise Jackett and Professor McLean were awarded first prize at the National Update in Pathology (a Royal College of Pathologists of Australia meeting) for their work on ‘Correlation of autopsy pathology with clinical diagnoses in life’. Appreciating the diagnoses that are missed provides an important contribution to improving clinical practice at Alfred Health.

Publications

Effect of Body Mass Index, Metabolic Health and Adipose Tissue Inflammation on the Severity of Non-alcoholic Fatty Liver Disease in Bariatric Surgical Patients: a Prospective Study

Ooi GJ, Burton PR, Bayliss J, Raajendiran A, Earnest A, Laurie C, Kemp WW, McLean CA, Roberts SK, Watt MJ, Brown WA

(2019), Obes Surg, 29(1), 99-108

DOI: 10.1007/s11695-018-3479-2

The interaction between irreversible electroporation therapy (IRE) and embolization material using a validated vegetal model: an experimental study

Chan P, McLean C, Chan S, Goh GS

(2019), DIAGN INTERV RADIOL, 25(4), 304-9

DOI: 10.5152/dir.2019.18361

The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis

Stock AT, Collins N, Smyth GK, Hu Y, Hansen JA, D'Silva DB, Jama HA, Lew AM, Gebhardt T, McLean CA, Wicks IP

(2019), J Immunol, 202(11), 3282-96

DOI: 10.4049/jimmunol.1900071

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