For researchers: Overview

Our services include:

• Isolation of DNA and RNA for genetic studies
• Isolation of plasma, serum or extraction of protein for proteomic studies
• Creation of PBMCs for biochemical research, and more

All sample information is entered into a laboratory information management system database (LIMS) for cataloguing, coding, and storage as well as integration of additional research data.

The ANB works closely with investigators and is committed to meet their comprehensive study goals.

Our mission

To become one of the largest and most diverse collections of samples from people with neurological disorders in the world. It is hoped that the ongoing cataloguing of bio-specimens and studies within the ANB will stimulate new opportunities for collaboration between the Biobank and domestic and international scientists to ultimately advance our ability to provide better management for common and rare neurological conditions.

Nature of the materials in the biobank

ANB stores the following biospecimens:

• Whole Blood
• DNA
• Plasma
• Serum
• RNA
• Separated cell populations from blood (e.g. Peripheral blood mononuclear cells, B-cells, macrophages, T-Cells, NK-cells)
• Brain tissue
• Cerebrospinal fluid
• Saliva
• Urine
• Skin Biopsies.

What kinds of information are associated with the banked samples?

Complete clinical follow up information as well as demographic information is available.

What kinds of materials do we provide to collaborating investigators?

Depending on the project, samples are provided to the investigators in a coded format.

Who has access to the banked samples?

Any investigators with novel projects that conform to the research goals of ANB may apply for the samples. Please refer to the ANB Bank Policy to determine if your project conforms to these goals. Priority is given to Alfred Health/Monash University Researchers/investigators. Since our tissue resources are extremely limited, we are able to collaborate with only those investigators with novel research and promising preliminary data who seek to verify their initial observations in a large-scale study.

Can genetic studies be proposed?

Yes, ANB accepts proposals for genetic studies, since we have the patient consent to support such studies. While genetic studies can be performed, the process requires a substantial resource allocation. Please contact us to get detailed information on this.

Is there a specific deadline for application?

No. The ANB accepts proposals anytime.

Where do i send the proposal?

Submit the proposal by emailing us your application at anb@alfred.org.au.

Is there a specific form that I have to use to apply for samples?

Yes. You must first submit a data and sample request form to request samples. The application at a minimum requires a defined hypothesis, specific aims, a description of the type and number of specimens required for the project.

Please find a copy of the application below.

Coupled with application for biospecimens or services, you will also be required to submit the following documentation to complete the application:

• Curriculum vitae of Principle Investigator (no longer than 2 pages)
• HREC (NEAF or equivalent) approval and amendment letters
• Complete HREC (NEAF or equivalent) application document or project protocol.

Is there a contact person in the ANB who is available for consultation before sending in the application?

Yes. For information on the review process and submission of an application, contact ANB Biobank Manager by e-mail (anb@alfred.org.au) or by phone at ph:(03)9903-0857.

How long does the approval process take?

Obtaining ethics approval from your institutional research ethics board (REB) or Alfred Hospital Ethics Committee should be straightforward and quick. As there is no further or direct contact with the donor patients and the data is “codified”, the review is categorized as “low risk”.

You will be notified of the decision/project approval by ANB within 1- 2 weeks. Upon approval, a collaborative agreement or Material transfer agreement will be signed between the participating institutions and then your project can commence!

If the proposed project does not already have an ethics approval from a Human Research Ethics Committee, an application can be submitted for review to the Alfred Hospital Ethics Committee.

Please visit the following page for further information:

It has been our experience that well prepared ethics applications can obtain ethics approval in as little as two to three weeks.

For further information on how to apply for a single site, low risk review and additional documents please visit the following page.

Does ANB fund the collaborative projects?

No. It is the investigator's responsibility to seek proper funding before contacting the ANB for samples. We do not provide samples to unfunded Non-Alfred Health investigators. However, for novel projects we may provide letters of support for new or continuing grant applications if approved by the ANB committee.