Cardiac imaging research
Professor Taylor’s group was the first in the world to utilize cardiac magnetic resonance (CMR) T1 mapping techniques to quantify diffuse myocardial fibrosis in humans, where it is associated with heart failure severity.
More recent research has linked diffuse fibrosis with increased cardiac stiffness as a putative mechanism for heart failure with preserved ejection fraction (HFpEF).
The group have also published numerous studies evaluating the relationship between regional myocardial fibrosis, assessed by conventional CMR late gadolinium enhancement, and sudden cardiac death, particularly in heart failure. Future research will focus on interventional studies aimed at regressing diffuse fibrosis in HFpEF, and the role of CMR in identifying heart failure patients at high risk of sudden death.
We have also developed a novel CMR method for the quantification of atrial stasis in atrial fibrillation (AF) and have documented its relationship to conventional markers of stroke risk. Additional studies will assess the relationship between atrial stasis in AF and cardio-embolic events, as well the relationship between atrial stasis and embolic stroke of uncertain significance (ESUS).
Effects of aldosterone blockade in hypertrophic cardiomyopathy
Find out more about the trial on ANZCTR
Dr. Gutman is a cardiologist at The Alfred specialising in heart failure, transplantation and non-invasive imaging (including cardiac MRI, cardiac CT and echocardiography).
