Alfred Health Pathology Services incorporates Laboratory Haematology, Microbiology and Clinical Biochemistry (also known as Chemical Pathology) and Anatomical Pathology.
This year’s report focuses on Haematology. Anatomical Pathology, headed by Professor Catriona McLean, is also reported.
Laboratory Haematology is primarily a diagnostic and consultative service providing expertise in blood banking, laboratory-based general haematology, including morphology, coagulation and flow cytometry, immunology tests and diagnostic bone marrow biopsies. The unit incorporates a specialist multidisciplinary transfusion medicine team which audits transfusion safety and practice.
Research collaborations involve identifying and supplying material for various registries of the Transfusion Outcomes Research Collaborative; Australia and New Zealand Intensive Care Society’s TRANSFUSE trial; Clinical Haematology and Trauma Unit clinical trials; Australian Centre for Blood Diseases (ACBD), Australasian Leukaemia and Lymphoma Group and Nucleus Network.
Current research includes:
- Development of highly sensitive flow cytometric techniques for detection of small volume minimal residual disease after potentially curative therapy, particularly in multiple myeloma and acute myeloid leukaemia (AML)
- Coagulopathy associated with mechanical circulatory assist devices and heart valve dysfunction (ACBD collaboration)
- PTP1B expression in myeloproliferative disorders as a marker of JAK-STAT pathway dysregulation
- Haematological and biochemical complications of dapsone therapy
- Predicting outcome in AML: molecular testing for founder mutations
- Blood product use in bone marrow transplant and cardiac surgery patients
- Pre-operative optimisation of hemoglobin in orthopedic patients to limit need for transfusion
- Dr Victoria Ling, Haematology RACP /RCPA Advanced Trainee, won the 2014 Victorian RACP Trainee Research Award for Excellence in Adult Medicine
- Dr Kay Htun, Haematology RACP /RCPA Advanced Trainee, won the 2014 Alfred Hospital prize for Best Advanced Physician Trainee Project
- Dr Mandy Davis, Haematologist and Transfusion Specialist, was awarded the WTMS (Whole Time Medical Specialist) grant of $56,000 for expansion of the BloodTrack program to improve safety of blood administration.
Acute Myeloid Leukaemia: predicting outcome
Disease aggressiveness and treatment responses in AML patients vary widely, despite cytogenetic prognostic categories at diagnosis broadly defining patient outcome.Find out more
Inappropriate pre-operative testing
Studies in the UK have determined that up to 25% of pathology testing is inappropriate or unnecessary.Find out more
Side effects of Ventricular Assist Devices (VADs)
Patients on ventricular assist devices or with some cardiac valve disorders develop bleeding complications due to the mechanical effect of shear stress on blood components.Find out more
Concentrating non-dilute urine before protein electrophoresis for the detection of monoclonal free light chains is unnecessary and wasteful
Haran H, Choy KW, Wijeratne N, Tudball R, Doery J, Grigoriadis G, Lu Z
(2018), Pathology, 50(5), 587-588
Mycobacterium abscessus complex: Natural history and treatment outcomes at a tertiary adult cystic fibrosis center
Tippett E, Ellis S, Wilson J, Kotsimbos T, Spelman D
(2018), Int J Mycobacteriol, 7(2), 109-116
Time to repeal and replace response criteria for acute myeloid leukemia?
Bloomfield CD, Estey E, Pleyer L, Schuh AC, Stein EM, Tallman MS, Wei A
(2018), Blood Rev, 32(5), 416-425