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Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals.

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Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis

N»bor, Danitza; Graber, Joel H.; Ciciotte, Steven L.; Robledo, Raymond F.; Papoin, Julien; Hartman, Emily; Gillinder, Kevin R.; Perkins, Andrew C.; Bieker, James J.; Blanc, Lionel; Peters, Luanne L.

(2018), Sci Rep, 8(1), 12793

DOI: 10.1038/s41598-018-30839-2

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

Conway, James R.W.; Warren, Sean C.; Herrmann, David; Murphy, Kendelle J.; Cazet, Aur»lie S.; Vennin, Claire; Shearer, Robert F.; Killen, Monica J.; Magenau, Astrid; M»l»nec, Pauline; Pinese, Mark; Nobis, Max; Zaratzian, Anaiis; Boulghourjian, Alice; Da Silva, Andrew M.; del Monte-Nieto, Gonzalo; Adam, Arne S.A.; Harvey, Richard P.; Haigh, Jody J.; Wang, Yingxiao; Croucher, David R.; Sansom, Owen J.; Pajic, Marina; Caldon, C. Elizabeth; Morton, Jennifer P.; Timpson, Paul

(2018), Cell Rep, 23(11), 3312-3326

DOI: 10.1016/j.celrep.2018.05.038

Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity

Tremblay, C»dric S.; Huang, Feng Fei; L»vesque, Georges; Carreau, Madeleine

(2018), BMC Res Notes, 11(1), 138

DOI: 10.1186/s13104-018-3243-7

Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis

Goldie, Stephen J.; Cottle, Denny L.; Tan, Fiona H.; Roslan, Suraya; Srivastava, Seema; Brady, Rhys; Partridge, Darren D.; Auden, Alana; Smyth, Ian M.; Jane, Stephen M.; Dworkin, Sebastian; Darido, Charbel

(2018), Cell Death Dis, 9(11), 1072

DOI: 10.1038/s41419-018-0901-6

Development of chondrocyte-seeded electrosprayed nanoparticles for repair of articular cartilage defects in rabbits

Yang, Shan Wei; Ku, Kai Chi; Chen, Shu Ying; Kuo, Shyh Ming; Chen, I. Fen; Wang, Ting Yi; Chang, Shwu Jen

(2018), J BIOMATER APPL, 32(6), 800-812

DOI: 10.1177/0885328217740729

A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury

Ziegler, M., Hohmann, J.D., Searle, A.K., Abraham, M.-K., Nandurkar, H.H., Wang, X., Peter, K.

(2018), Eur Heart J, 111-116

DOI: 10.1093/eurheartj/ehx218

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages

Samudra, A.N., Dwyer, K.M., Selan, C., Freddi, S., Murray-Segal, L., Nikpour, M., Hickey, M.J., Peter, K., Robson, S.C., Sashindranath, M., Cowan, P.J., Nandurkar, H.H.

(2018), J Autoimmun, 131-138

DOI: 10.1016/j.jaut.2017.10.009

Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome

Kraakman, M.J., Kammoun, H.L., Dragoljevic, D., Al-Sharea, A., Lee, M.K.S., Flynn, M.C., Stolz, C.J., Guirguis, A.A., Lancaster, G.I., Chin-Dusting, J., Curtis, D.J., Murphy, A.J.

(2018), Haematologica, 597-606

DOI: 10.3324/haematol.2017.181958

The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers

Bain, C.R., Draxler, D.F., Taylor, R., Wallace, S., Gouldthorpe, O., Corcoran, T.B., Myles, P.S., L. Medcalf, R., Bozaoglu, K.

(2018), Anaesthesia, 955-966

DOI: 10.1111/anae.14306

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE

(2018), Cancer Discov, 8(12), 1582-1597

DOI: 10.1158/2159-8290.CD-18-0387

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

Teh TC, Nguyen NY, Moujalled DM, Segal D, Pomilio G, Rijal S, Jabbour A, Cummins K, Lackovic K, Blombery P, Thompson E, Ekert PG, Lessene G, Glaser SP, Huang DCS, Roberts AW, Guthridge MA, Wei AH

(2018), Leukemia, 32(2), 303-312

DOI: 10.1038/leu.2017.243

Dissecting causes for improved survival among patients with acute myeloid leukemia in two different eras receiving identical regimens in sequential randomized studies

Tiong IS, Reynolds J, Bradstock KF, Seymour JF, Wei AH; Australasian Leukaemia & Lymphoma Group

(2018), Blood Cancer J, 8(9), 84

DOI: 10.1038/s41408-018-0121-4

DCEP as a bridge to ongoing therapies for advanced relapsed and/or refractory multiple myeloma

Yuen HLA, Low MSY, Fedele P, Kalff A, Walker P, Bergin K, Coutsouvelis J, Grigoriadis G, Spencer A

(2018), Leuk Lymphoma, 59(12), 2842-2846

DOI: 10.1080/10428194.2018.1454595

Phase Ib study of the mTOR inhibitor everolimus with low dose cytarabine in elderly acute myeloid leukemia

Tiong IS, Tan P, McManus J, Cummings N, Sadawarte S, Catalano J, Hills R, Wei A

(2018), Leuk Lymphoma, 59(2), 493-496

DOI: 10.1080/10428194.2017.1334122

Autoregulation of von Willebrand factor function by a disulfide bond switch

Butera D, Passam F, Ju L, Cook KM, Woon H, Aponte-SantamarÃa C, Gardiner E, Davis AK, Murphy DA, Bronowska A, Luken BM, Baldauf C, Jackson S, Andrews R, Grâter F, Hogg PJ

(2018), Sci Adv, 4(2), eaaq1477

DOI: 10.1126/sciadv.aaq1477

Mechanisms of platelet dysfunction in patients with implantable devices

Casan J, Andrews RK, Gardiner EE, Davis AK

(2018), Semin Thromb Hemost, 44(1), 43808

DOI: 10.1055/s-0037-1605572

Low T-cell responses to mitogen stimulation predicts poor survival in recipients of allogeneic hematopoietic stem cell transplantation

Yong MK, Cameron PU, Slavin MA, Cheng AC, Morrissey CO, Bergin K, Spencer A, Ritchie D, Lewin SR

(2017), Front Immunol, 8, 1506

DOI: 10.3389/fimmu.2017.01506

Basic mechanisms of platelet receptor shedding

Andrews RK, Gardiner EE