Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Conway AJ, Brown FC, Fullinfaw RO, Kile BT, Jane SM, Curtis DJ

(2017), Dis Model Mech, 10(8), 1005-13

DOI: 10.1242/dmm.029116

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, MartÃn MT, Guillamot M, Banh RS, Xu M, Figueroa ME, Dickins RA, Abdel-Wahab O, Park CY, Tsirigos A, Neel BG, Aifantis I

(2017), Cell, 170(6), 1079-95.e20

DOI: 10.1016/j.cell.2017.07.032

Generation of an inducible mouse model to reversibly silence Stat3

Alorro MG, Pierce TP, Eissmann MF, Dijkstra C, Dickins RA, Ernst M, Buchert M, Masson F

(2017), Genesis, 55(4), e23023

DOI: 10.1002/dvg.23023

Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Dai Y, Guo J, Wang TY, Ju Y, Mitchell AJ, Bonnard T, Cui J, Richardson JJ, Hagemeyer CE, Alt K, Caruso F

(2017), Adv Healthc Mater, 6(16), 1700467

DOI: 10.1002/adhm.201700467

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening

Brazilek RJ, Tovar-Lopez FJ, Wong AKT, Tran H, Davis AS, McFadyen JD, Kaplan Z, Chunilal S, Jackson SP, Nandurkar H, Mitchell A, Nesbitt WS

(2017), Lab Chip, 17(15), 2595-608

DOI: 10.1039/c7lc00498b

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals.

Trevillyan JM, Gardiner EE, Andrews RK, Maisa A, Hearps AC, Al-Tamimi M, Crowe SM, Hoy JF

(2017), Platelets, 28(3), 301-4

DOI: 10.1080/09537104.2016.1237627

Platelet hyperreactivity in diabetes: focus on GPVI signaling-are useful drugs already available?

Arthur JF, Jandeleit-Dahm K, Andrews RK

(2017), Diabetes, 66(1), 7-13

DOI: 10.2337/db16-1098

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood SE, Richart AL, Henstridge DC, Alt K, Kiriazis H, Zammit C, Carey AL, Kammoun HL, Delbridge LM, Reddy M, Chen YC, Du XJ, Hagemeyer CE, Febbraio MA, Siebel AL, Kingwell BA

(2017), Sci Transl Med, 9(411), eaam6084

DOI: 10.1126/scitranslmed.aam6084

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy CP, Yao Y, Kammoun H, Bonnard T, Hoefer T, Alt K, Tovar-Lopez F, Rosengarten G, Ramsland PA, van der Meer AD, van den Berg A, Murphy AJ, Hagemeyer CE, Peter K, Westein E

(2017), J Thromb Haemost, 15(5), 972-82

DOI: 10.1111/jth.13666

Pharmacokinetics and safety of carfilzomib in patients with relapsed multiple myeloma and end-stage renal disease (ESRD): an open-label, single-arm, phase I study

Quach H, White D, Spencer A, Ho PJ, Bhutani D, White M, Inamdar S, Morris C, Ou Y, Gyger M

(2017), Cancer Chemother Pharmacol, 79(6), 1067-76

DOI: 10.1007/s00280-017-3287-8

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

Stone RM, Mandrekar SJ, Sanford BL, Laumann K, Geyer S, Bloomfield CD, Thiede C, Prior TW, Dàhner K, Marcucci G, Lo-Coco F, Klisovic RB, Wei A, Sierra J, Sanz MA, Brandwein JM, de Witte T, Niederwieser D, Appelbaum FR, Medeiros BC, Tallman MS, Krauter J, Schlenk RF, Ganser A, Serve H, Ehninger G, Amadori S, Larson RA, Dàhner H

(2017), N Engl J Med, 377(5), 454-64

DOI: 10.1056/NEJMoa1614359

An individualised risk-adapted protocol of pre- and post transplant zoledronic acid reduces bone loss after allogeneic stem cell transplantation: results of a phase II prospective trial

Grigg A, Butcher B, Khodr B, Bajel A, Hertzberg M, Patil S, D'Souza AB, Ganly P, Ebeling P, Wong E

(2017), Bone Marrow Transplant, 52(9), 1288-93

DOI: 10.1038/bmt.2017.108

Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results

Hughes TP, Leber B, Cervantes F, Spector N, Pasquini R, Clementino NCD, Schwarer AP, Dorlhiac-Llacer PE, Mahon FX, Rea D, Guerci-Bresler A, Kamel-Reid S, Bendit I, Acharya S, Glynos T, Dalal D, Branford S, Lipton JH

(2017), Leukemia, 31(11), 2529-31

DOI: 10.1038/leu.2017.247

Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury

Ziegler M, Wang X, Lim B, Leitner E, Klingberg F, Ching V, Yao Y, Huang D, Gao XM, Kiriazis H, Du XJ, Haigh JJ, Bobik A, Hagemeyer CE, Ahrens I, Peter K

(2017), Theranostics, 7(13), 3192-206

DOI: 10.7150/thno.19698

Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury

Sashindranath M, Dwyer KM, Dezfouli S, Selan C, Crikis S, Lu B, Yuan Y, Hickey MJ, Peter K, Robson SC, Cowan PJ, Nandurkar HH

(2017), Purinergic Signal, 13(2), 259-65

DOI: 10.1007/s11302-017-9558-3

Novel thrombolytic drug based on thrombin cleavable microplasminogen coupled to a single-chain antibody specific for activated GPIIb/IIIa

Bonnard T, Tennant Z, Niego B, Kanojia R, Alt K, Jagdale S, Law LS, Rigby S, Medcalf RL, Peter K, Hagemeyer CE

(2017), J Am Heart Assoc, 6(2), e004535

DOI: 10.1161/JAHA.116.004535

An evidence-based approach to myeloma bone disease

Bingham N, Reale A, Spencer A

(2017), Curr Hematol Malig Rep, 12(2), 109-18

DOI: 10.1007/s11899-017-0370-5

The incidence and natural history of dasatinib complications in the treatment of chronic myeloid leukemia

Fox LC, Cummins KD, Costello B, Yeung D, Cleary R, Forsyth C, Tatarczuch M, Burbury K, Motorna O, Shortt J, Fleming S, McQuillan A, Schwarer A, Harrup R, Holmes A, Ratnasingam S, Chan KL, Hsu WH, Ashraf A, Putt F, Grigg A

(2017), Blood Adv, 1(13), 802-11

DOI: 10.1182/bloodadvances.2016003889

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP

(2017), Sci Transl Med, 9(409), eaam5861

DOI: 10.1126/scitranslmed.aam5861

Anti-fibrinolytics

Draxler DF, Medcalf RL, Gruen RL

(2016), In: Gonzalez E, Moore HB, Moore EE (eds), Trauma Induced Coagulopathy, Springer International Publishing,

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