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Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals.

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A clinical perspective of anti-fibrotic therapies for cardiovascular disease

Fang L, Murphy AJ, Dart AM

(2017), Front Pharmacol, 8, 186

DOI: 10.3389/fphar.2017.00186

Systemic inflammation is associated with myocardial fibrosis, diastolic dysfunction, and cardiac hypertrophy in patients with hypertrophic cardiomyopathy

Fang L, Ellims AH, Beale AL, Taylor AJ, Murphy A, Dart AM

(2017), Am J Transl Res, 9(11), 5063-73

Caudal fluoroscopy to guide venous access for pacemaker device implantation: should this now be standard practice?

Patel HC, Hayward C, Nanayakkara S, Broughton A, Mariani JA

(2017), Heart Asia, 9(1), 68-9

DOI: 10.1136/heartasia-2017-010881

Cardiac implantable electronic device hematomas: risk factors and effect of prophylactic pressure bandaging

Koh Y, Bingham NE, Law N, Le D, Mariani JA

(2017), Pacing Clin Electrophysiol, 40(7), 857-67

DOI: 10.1111/pace.13106

Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat

Tate M, Deo M, Cao AH, Hood SG, Huynh K, Kiriazis H, Du XJ, Julius TL, Figtree GA, Dusting GJ, Kaye DM, Ritchie RH

(2017), Diab Vasc Dis Res, 14(5), 423-33

DOI: 10.1177/1479164117710390

N-Acetylcysteine attenuates the development of renal fibrosis in transgenic mice with dilated cardiomyopathy

Giam B, Kuruppu S, Chu PY, Smith AI, Marques FZ, Fiedler A, Horlock D, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW

(2017), Sci Rep, 7, 17718

DOI: 10.1038/s41598-017-17927-5

Impaired right heart and pulmonary vascular function in HFpEF: time for more risk markers?

Kaye DM, Marwick TH

(2017), JACC Cardiovasc Imaging, 10(10 Pt B), 1222-4

DOI: 10.1016/j.jcmg.2016.12.023

Understanding the role of the LA in functional responses to heart failure

Marwick TH, Kaye D

(2017), JACC Cardiovasc Imaging, 10(10 Pt B), 1265-7

DOI: 10.1016/j.jcmg.2016.10.006

The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy

De Blasio MJ, Ramalingam A, Cao AH, Prakoso D, Ye JM, Pickering R, Watson AMD, de Haan JB, Kaye DM, Ritchie RH

(2017), Eur J Pharmacol, 807, 12-20

DOI: 10.1016/j.ejphar.2017.04.026

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Qin CX, May LT, Li R, Cao N, Rosli S, Deo M, Alexander AE, Horlock D, Bourke JE, Yang YH, Stewart AG, Kaye DM, Du XJ, Sexton PM, Christopoulos A, Gao XM, Ritchie RH

(2017), Nat Commun, 8, 14232

DOI: 10.1038/ncomms14232

High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice

Marques FZ, Nelson E, Chu PY, Horlock D, Fiedler A, Ziemann M, Tan JK, Kuruppu S, Rajapakse NW, El-Osta A, Mackay CR, Kaye DM

(2017), Circulation, 135(10), 964-77

DOI: 10.1161/CIRCULATIONAHA.116.024545

Cardiac gene delivery using recirculating devices

Byrne MJ, Kaye DM

(2017), In: Ishikawa K (ed), Methods in Molecular Biology, volume 1521, Cardiac Gene Therapy: Methods and Protocols, Springer, Chapter 19, 261-9

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling

Furtado MB, Wilmanns JC, Chandran A, Perera J, Hon O, Biben C, Willow TJ, Nim HT, Kaur G, Simonds S, Wu Q, Willians D, Salimova E, Plachta N, Denegre JM, Murray SA, Fatkin D, Cowley M, Pearson JT, Kaye D, Ramialison M, Harvey RP, Rosenthal NA, Costa MW

(2017), JCI Insight, 2(6), e88271

DOI: 10.1172/jci.insight.88271

Atrial fibrillation and heart failure - cause or effect?

Prabhu S, Voskoboinik A, Kaye DM, Kistler PM

(2017), Heart Lung Circ, 26(9), 967-74

DOI: 10.1016/j.hlc.2017.05.117

Catheter ablation versus medical rate control in atrial fibrillation and systolic dysfunction: the CAMERA-MRI study

Prabhu S, Taylor AJ, Costello BT, Kaye DM, McLellan AA, Voskoboinik A, Sugumar H, Lockwood SM, Stokes MB, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Gutman S, Lee G, Layland J, Mariani JA, Ling LH, Kalman JM, Kistler PM

(2017), J Am Coll Cardiol, 70(16), 1949-61

DOI: 10.1016/j.jacc.2017.08.041

Impact of atrial fibrillation on rest and exercise haemodynamics in heart failure with mid-range and preserved ejection fraction

Kaye DM, Silvestry FE, Gustafsson F, Cleland JG, van Veldhuisen DJ, Ponikowski P, Komtebedde J, Nanayakkara S, Burkhoff D, Shah SJ

(2017), Eur J Heart Fail, 19(12), 1690-7

DOI: 10.1002/ejhf.930

A randomized double-blind trial of an interventional device treatment of functional mitral regurgitation in patients with symptomatic congestive heart failure-Trial design of the REDUCE FMR study

Goldberg SL, Meredith I, Marwick T, Haluska BA, Lipiecki J, Siminiak T, Mehta N, Kaye DM, Sievert H; REDUCE FMR Investigators

(2017), Am Heart J, 188, 167-74

DOI: 10.1016/j.ahj.2017.02.032

Hemodynamic profile of patients with heart failure and preserved ejection fraction vary by age

Nanayakkara S, Haykowsky M, Mariani J, Van Empel V, Maeder MT, Vizi D, Kaye DM

(2017), J Am Heart Assoc, 6(9), e005434

DOI: 10.1161/JAHA.116.005434

Extended release oral milrinone as an adjunct to heart failure therapy

Nanayakkara S, Bergin P, Mak V, Crannitch K, Kaye D

(2017), Intern Med J, 47(8), 973-4

DOI: 10.1111/imj.13503

Emerging therapies for heart failure with preserved ejection fraction