Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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The Snail Family in Normal and Malignant Haematopoiesis

Carmichael CL, Haigh JJ

(2017), Cells Tissues Organs, 203(2), 82-98

DOI: 10.1159/000448655

Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice

Dworkin S, Auden A, Partridge DD, Daglas M, Medcalf RL, Mantamadiotis T, Georgy SR, Darido C, Jane SM, Ting SB

(2017), Dev Neurobiol, 77(6), 775-88

DOI: 10.1002/dneu.22469

Did He Who Made the Lamb Make Thee? New Developments in Treating the Fearful Symmetry of Acute Myeloid Leukemia

Brumatti G, Lalaoui N, Wei AH, Silke J

(2017), Trends Mol Med, 23(3), 264-281

DOI: 10.1016/j.molmed.2017.01.005

Myeloma in the real world: what is really happening?

Bergin K, McQuilten Z, Moore E, Wood E, Spencer A

(2017), Clin Lymphoma Myeloma Leuk, 17(3), 133-44.e1

DOI: 10.1016/j.clml.2016.12.002

The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia

Tan P, Tiong IS, Fleming S, Pomilio G, Cummings N, Droogleever M, McManus J, Schwarer A, Catalano J, Patil S, Avery S, Spencer A, Wei A

(2017), Oncotarget, 8(32), 52269-80

DOI: 10.18632/oncotarget.13699

Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia

Kantarjian H, Stein A, Gàkbuget N, Fielding AK, Schuh AC, Ribera JM, Wei A, Dombret H, Foá R, Bassan R, Arslan Ö, Sanz MA, Bergeron J, Demirkan F, Lech-Maranda E, Rambaldi A, Thomas X, Horst HA, Br?ggemann M, Klapper W, Wood BL, Fleishman A, Nagorsen D, Holland C, Zimmerman Z, Topp MS

(2017), N Engl J Med, 376(9), 836-47

DOI: 10.1056/NEJMoa1609783

Metabolic gatekeeper function of B-lymphoid transcription factors

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, S?nchez-GarcÃa I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, M?schen M

(2017), Nature, 542(7642), 479-83

DOI: 10.1038/nature21076

Idarubicin Dose Escalation During Consolidation Therapy for Adult Acute Myeloid Leukemia

Bradstock KF, Link E, Di Iulio J, Szer J, Marlton P, Wei AH, Enno A, Schwarer A, Lewis ID, D'Rozario J, Coyle L, Cull G, Campbell P, Leahy MF, Hahn U, Cannell P, Tiley C, Lowenthal RM, Moore J, Cartwright K, Cunningham I, Taper J, Grigg A, Roberts AW, Benson W, Hertzberg M, Deveridge S, Rowlings P, Mills AK, Gill D, Bardy P, Campbell L, Seymour JF; Australasian Leukaemia & Lymphoma Group

(2017), J Clin Oncol, 35(15), 1678-85

DOI: 10.1200/JCO.2016.70.6374

Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma

Mithraprabhu S, Khong T, Ramachandran M, Chow A, Klarica D, Mai L, Walsh S, Broemeling D, Marziali A, Wiggin M, Hocking J, Kalff A, Durie B, Spencer A

(2017), Leukemia, 31(8), 1695-705

DOI: 10.1038/leu.2016.366

Partial response after induction chemotherapy has clinical relevance in acute myeloid leukaemia

Fleming S, Ong DM, Jackson K, Avery S, Mollee P, Marlton P, Kennedy G, Wei AH

(2017), Br J Haematol, 177(2), 328-30

DOI: 10.1111/bjh.14063

Genomic characterisation of EΜ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Lefebure M, Tothill RW, Kruse E, Hawkins ED, Shortt J, Matthews GM, Gregory GP, Martin BP, Kelly MJ, Todorovski I, Doyle MA, Lupat R, Li J, Schroeder J, Wall M, Craig S, Poortinga G, Cameron D, Bywater M, Kats L, Gearhart MD, Bardwell VJ, Dickins RA, Hannan RD, Papenfuss AT, Johnstone RW

(2017), Nat Commun, 8, 14581

DOI: 10.1038/ncomms14581

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

Witkowski MT, Hu Y, Roberts KG, Boer JM, McKenzie MD, Liu GJ, Le Grice OD, Tremblay CS, Ghisi M, Willson TA, Horstmann MA, Aifantis I, Cimmino L, Frietze S, den Boer ML, Mullighan CG, Smyth GK, Dickins RA

(2017), J Exp Med, 214(3), 773-9

DOI: 10.1084/jem.20160048

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

Ginn SL, Hallwirth CV, Liao SH, Teber ET, Arthur JW, Wu J, Lee HC, Tay SS, Hu M, Reddel RR, McCormack MP, Thrasher AJ, Cavazzana M, Alexander SI, Alexander IE

(2017), Mol Ther Nucleic Acids, 6, 1-14

DOI: 10.1016/j.omtn.2016.11.011

A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood

Draxler DF, Madondo MT, Hanafi G, Plebanski M, Medcalf RL

(2017), Cytom Part A, 91(4), 336-50

DOI: 10.1002/cyto.a.23080

Significant age, race and gender differences in global coagulation assays parameters in the normal population

Ho P, Ng C, Rigano J, Tacey M, Smith C, Donnan G, Nandurkar H

(2017), Thromb Res, 154, 80-3

DOI: 10.1016/j.thromres.2017.04.009

High rates of potentially infectious exposures between immunocompromised patients and their companion animals: an unmet need for education. Gurry GA, Campion V, Premawardena C, Woolley I, Shortt J, Bowden DK, Kaplan Z, Dendle C

Gurry GA, Campion V, Premawardena C, Woolley I, Shortt J, Bowden DK, Kaplan Z, Dendle C

(2017), Intern Med J, 7(3), 333-5

DOI: 10.1111/imj.13361

Specification of neurotransmitter identity by Tal1 in thalamic nuclei

Lee B, Lee M, Song S, Loi LD, Lam DT, Yoon J, Baek K, Curtis DJ, Jeong Y

(2017), Dev Dyn, 246(10), 749-58

DOI: 10.1002/dvdy.24546

Fibrinolysis: Biochemistry, Clinical Aspects, and Therapeutic Potential

Kwaan H, Lisman T, Medcalf RL

(2017), Semin Thromb Hemost, 43(2), 113-4

DOI: 10.1055/s-0036-1598000

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Green TN, Hamilton JR, Morel-Kopp MC, Zheng Z, Chen TT, Hearn JI, Sun PP, Flanagan JU, Young D, Barber PA, During MJ, Ward CM, Kalev-Zylinska ML

(2017), Platelets, 28(8), 799-811

DOI: 10.1080/09537104.2017.1280149

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ

(2017), Blood, 129(8), 981-90

DOI: 10.1182/blood-2016-06-721191

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