Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia

Kipps TJ, Eradat H, Grosicki S, Catalano J, Cosolo W, Dyagil IS, Yalamanchili S, Chai A, Sahasranaman S, Punnoose E, Hurst D, Pylypenko H

(2015), Leuk Lymphoma, 56(10), 2826-33

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

Dimopoulos MA, Weisel KC, Song KW, Delforge M, Karlin L, Goldschmidt H, Moreau P, Banos A, Oriol A, Garderet L, Cavo M, Ivanova V, Alegre A, Martinez-Lopez J, Chen C, Spencer A, Knop S, Bahlis NJ, Renner C, Yu X, Hong K, Sternas L, Jacques C, Zaki MH, San Miguel JF

(2015), Haematologica, 100(10), 1327-33

An analysis of the thromboembolic outcomes of 2472 splenectomized individuals

Dendle C, Spelman T, Sundararajan V, Chunilal S, Woolley I

(2015), Blood, 125(10), 1681-2

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Van Overbeke W, Wongsantichon J, Everaert I, Verhelle A, Zwaenepoel O, Loonchanta A, Burtnick LD, De Ganck A, Hochepied T, Haigh J, Cuvelier C, Derave W, Robinson RC, Gettemans J

(2015), Hum Mol Genet, 24(9), 2492-507

Effects of abacavir administration on structural and functional markers of platelet activation

Trevillyan JM, Arthur JF, Jing J, Andrews RK, Gardiner EE, Hoy JF

(2015), AIDS, 29(17), 2309-13

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

Su EJ, Fredriksson L, Kanzawa M, Moore S, Folestad E, Stevenson TK, Nilsson I, Sashindranath M, Schielke GP, Warnock M, Ragsdale M, Mann K, Lawrence AL, Medcalf RL, Eriksson U, Murphy GG, Lawrence DA

(2015), Front Cell Neurosci, 9, 385

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Shultz SR, Wright DK, Zheng P, Stuchbery R, Liu SJ, Sashindranath M, Medcalf RL, Johnston LA, Hovens CM, Jones NC, O'Brien TJ

(2015), Brain, 138(Pt 5), 1297-313

Evaluation of gait impairment in mice subjected to craniotomy and traumatic brain injury

Sashindranath M, Daglas M, Medcalf RL

(2015), Behav Brain Res, 286, 33-8

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets

Sánchez Guiu IM, Martínez-Martinez I, Martínez C, Navarro-Fernandez J, García-Candel F, Ferrer-Marín F, Vicente V, Watson SP, Andrews RK, Gardiner EE, Lozano ML1, Rivera J

(2015), Thromb Haemost, 114(2), 313-24

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Samson AL, Ju L, Ah Kim H, Zhang SR, Lee JA, Sturgeon SA, Sobey CG, Jackson SP, Schoenwaelder SM

(2015), Sci Rep, 5, 16171

Global regulator MorA affects virulence-associated protease secretion in Pseudomonas aeruginosa PAO1

Ravichandran A, Ramachandran M, Suriyanarayanan T, Wong CC, Swarup S

(2015), PLoS One, 10(4), e0123805

The platelet Fc receptor, FcγRIIa

Qiao J, Al-Tamimi M, Baker RI, Andrews RK, Gardiner EE

(2015), Immunol Rev, 268(1), 241-52

Methods to determine the lagrangian shear experienced by platelets during thrombus growth

Pinar IP, Arthur JF, Andrews RK, Gardiner EE, Ryan K, Carberry J

(2015), PLoS One, 10(12), e0144860

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson LJ, Segal DH, Nero TL, Parker MW, Wan SS, de Silva M, Guthridge MA, Wei AH, Burns CJ

(2015), Bioorg Med Chem, 23(19), 6280-96

Asymmetric cell division during T cell development controls downstream fate

Pham K, Shimoni R, Charnley M, Ludford-Menting MJ, Hawkins ED, Ramsbottom K, Oliaro J, Izon D, Ting SB, Reynolds J, Lythe G, Molina-Paris C, Melichar H, Robey E, Humbert PO, Gu M, Russell SM

(2015), J Cell Biol, 210(6), 933-50

MYB elongation is regulated by the nucleic acid binding of NFΚB p50 to the intronic stem-loop region

Pereira LA, Hugo HJ, Malaterre J, Huiling X, Sonza S, Cures A, Purcell DF, Ramsland PA, Gerondakis S, Gonda TJ, Ramsay RG

(2015), PLoS One, 10(4), e0122919

Loss of c-REL but not NF-ΚB2 prevents autoimmune disease driven by FasL mutation

O'Reilly LA, Hughes P, Lin A, Waring P, Siebenlist U, Jain R, Gray DH, Gerondakis S, Strasser A

(2015), Cell Death Differ, 22(5), 767-78

Class II but not second class-prospects for the development of class II PI3K inhibitors

Mountford SJ, Zheng Z, Sundaram K, Jennings IG, Hamilton JR, Thompson PE

(2015), ACS Med Chem Lett, 6(1), 3-6

The class II PI 3-kinase, PI3KC2{alpha}, links platelet internal membrane structure to shear-dependent adhesive function

Mountford JK, Petitjean C, Putra HW, McCafferty JA, Setiabakti NM, Lee H, TØnnesen LL, McFadyen JD, Schoenwaelder SM, Eckly A, Gachet C, Ellis S, Voss AK, Dickins RA, Hamilton JR, Jackson SP

(2015), Nat Commun, 6, 6535

Current state and novel approaches of antiplatelet therapy

Metharom P, Berndt MC, Baker RI, Andrews RK

(2015), Arterioscler Thromb Vasc Biol, 35(6), 1327-38

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