Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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The X-ray crystal structure of full-length human plasminogen

Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, Steer D, Cowan A, Zhang Q, Lu BG, Pike RN, Smith AI, Coughlin PB, Whisstock JC

(2012), Cell Rep, 1(3), 185-90

Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease

Lancaster GI, Kowalski GM, Estevez E, Kraakman MJ, Grigoriadis G, Febbraio MA, Gerondakis S, Banerjee A

(2012), PLoS One, 7(6), e39100

Relative efficacy of steroid therapy in immune thrombocytopenia mediated by anti-platelet GPIIbIIIa versus GPIbα antibodies

Zeng Q, Zhu L, Tao L, Bao J, Yang M, Simpson EK, Li C, van der Wal DE, Chen P, Spring CM, Wang M, Zhang L, Ruan C, Hou M, Xia R, Ni H

(2012), Am J Hematol, 87(2), 206-8

Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain

Wu F, Wu J, Nicholson AD, Echeverry R, Haile WB, Catano M, An J, Lee AK, Duong D, Dammer EB, Seyfried NT, Tong FC, Votaw JR, Medcalf RL, Yepes M

(2012), J Neurosci, 32(29), 9848-58

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

White MJ, Schoenwaelder SM, Josefsson EC, Jarman KE, Henley KJ, James C, Debrincat MA, Jackson SP, Huang DC, Kile BT

(2012), Blood, 119(18), 4283-90

Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα--14-3-3ζ] association

van der Wal DE, Gitz E, Du VX, Lo KS, Koekman CA, Versteeg S, Akkerman JW

(2012), Haematologica, 97(10), 1514-22

Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2

Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G

(2012), Blood, 119(11), 2510-22

Tissue plasminogen activator does not alter development of acquired epilepsy

Tan ML, Ng A, Pandher PS, Sashindranath M, Hamilton JA, Davis SM, O'Brien TJ, Medcalf RL, Yan B, Jones NC

(2012), Epilepsia, 53(11), 1998-2004

Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

Slape CI, Saw J, Jowett JB, Aplan PD, Strasser A, Jane SM, Curtis DJ

(2012), Blood, 120(12), 2475-83

Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function

Schoenwaelder SM, Jackson SP

(2012), Blood, 119(5), 1320-1

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

Sashindranath M, Sales E, Daglas M, Freeman R, Samson AL, Cops EJ, Beckham S, Galle A, McLean C, Morganti-Kossmann C, Rosenfeld JV, Madani R, Vassalli JD, Su EJ, Lawrence DA, Medcalf RL

(2012), Brain, 135(Pt 11), 3251-64

Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death

Sandow JJ, Jabbour AM, Condina MR, Daunt CP, Stomski FC, Green BD, Riffkin CD, Hoffmann P, Guthridge MA, Silke J, Lopez AF, Ekert PG

(2012), Cell Death Differ, 19(4), 633-41

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin

Samson AL, Knaupp AS, Sashindranath M, Borg RJ, Au AE, Cops EJ, Saunders HM, Cody SH, McLean CA, Nowell CJ, Hughes VA, Bottomley SP, Medcalf RL

(2012), Cell Rep, 2(4), 889-901

The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms

Nourse JP, Lea R, Crooks P, Wright G, Tran H, Catalano J, Brighton T, Grigg A, Marlton P, Gandhi MK

(2012), Blood Coagul Fibrinolysis, 23(1), 45-50

t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

Niego B, Freeman R, Puschmann TB, Turnley AM, Medcalf RL

(2012), Blood, 119(20), 4752-61

Wnt1 is anti-lymphangiogenic in a melanoma mouse model

Niederleithner H, Heinz M, Tauber S, Bilban M, Pehamberger H, Sonderegger S, Knöfler M, Bracher A, Berger W, Loewe R, Petzelbauer P

(2012), J Invest Dermatol, 132(9), 2235-44

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

Nesbitt WS, Harper IS, Schoenwaelder SM, Yuan Y, Jackson SP

(2012), Methods Mol Biol, 788, 73-89

Plasminogen activation and thrombolysis for ischemic stroke

Medcalf RL, Davis SM

(2012), Int J Stroke, 7(5), 419-25

Desmoteplase: discovery, insights and opportunities for ischaemic stroke

Medcalf RL

(2012), Br J Pharmacol, 165(1), 75-89

Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period

McLintock C, Brighton T, Chunilal S, Dekker G, McDonnell N, McRae S, Muller P, Tran H, Walters BN, Young L; Councils of the Society of Obstetric Medicine of Australia and New Zealand; Australasian Society of Thrombosis and Haemostasis

(2012), Aust N Z J Obstet Gynaecol, 52(1), 14-22

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