Research publications

PKC412 demonstrates JNK-dependent activity against human multiple myeloma cells

Sharkey J, Khong T, Spencer A

(2007), Blood, 109(4), 1712-9

Identification of a unique co-operative phosphoinositide 3-kinase signalling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets

Schoenwaelder SM, Ono A, Sturgeon S, Chan SM, Mangin P, Maxwell MJ, Turnbull S,Mulchandani M, Anderson K, Kauffenstein G, Rewcastle GW, Kendall J, Gachet C, Salem HH, Jackson SP

(2007), J Biol Chem, 282(39), 28648-58

Molecular characterization of centerin, a germinal centre cell serpin

Paterson MA, Horvath AJ, Pike RN, Coughlin PB

(2007), Biochem J, 405(3), 489-94

Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression

Orlowski RZ, Nagler A, Sonneveld P, Bladé J, Hajek R, Spencer A, San Miguel J, Robak T, Dmoszynska A, Horvath N, Spicka I, Sutherland HJ, Suvorov AN, Zhuang SH, Parekh T, Xiu L, Yuan Z, Rackoff W, Harousseau JL

(2007), J Clin Oncol, 25(25), 3892-901

Fibrinolysis, inflammation, and regulation of the plasminogen activating system

Medcalf RL

(2007), J Thromb Haemost, 5 (Suppl 1), 132-42

Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation

Maxwell MJ, Westein E, Nesbitt WS, Giuliano S, Dopheide SM, Jackson SP

(2007), Blood, 109(2), 566-76

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

Lindemann RK, Newbold A, Whitecross KF, Cluse LA, Frew AJ, Ellis L, Williams S, Wiegmans AP, Dear AE, Scott CL, Pellegrini M, Wei A, Richon VM, Marks PA, Lowe SW, Smyth MJ, Johnstone RW

(2007), Proc Natl Acad Sci USA, 104(19), 8071-6

Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform

Kim S, Garcia A, Jackson SP, Kunapuli SP

(2007), Blood, 110(13), 4206-13

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors

Kendall JD, Rewcastle GW, Frederick R, Mawson C, Denny WA, Marshall ES, Baguley BC, Chaussade C, Jackson SP, Shepherd PR

(2007), Bioorg Med Chem, 15(24), 7677-87

The growing complexity of platelet aggregation

Jackson SP

(2007), Blood, 109(12), 5087-95

Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb

Jackson SP, Cranmer S, Mangin P, Yuan Y

(2007), Blood, 109(2), 846-7

Differential regulation of adapter proteins Dok2 and Dok1 in platelets, leading to an association of Dok2 with integrin alphaIIbbeta3

Hughan SC, Watson SP

(2007), J Thromb Haemost, 5(2), 387-94

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk

Hughan SC, Hughes CE, McCarty OJ, Schweighoffer E, Soultanova I, Ware J, Tybulewicz VL, Watson SP

(2007), Arterioscler Thromb Vasc Biol, 27(2), 422-9

Antiplatelet therapy: present status and future prospects

Hamilton JR, Kaplan Z, Jackson SP, Opat S

(2007), Expert Opin Drug Dis, 2(8), 1035-40

Association between osteopontin and human abdominal aortic aneurysm

Golledge J, Muller J, Shephard N, Clancy P, Smallwood L, Moran C, Dear AE, Palmer LJ, Norman PE

(2007), Arterioscler Thromb Vasc Biol, 27(3), 655-60

PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis

Ferguson GJ, Milne L, Kulkarni S, Sasaki T, Walker S, Andrews S, Crabbe T, Finan P, Jones G, Jackson S, Camps M, Rommel C, Wymann M, Hirsch E, Hawkins P, Stephens L

(2007), Nat Cell Biol, 9(1), 86-91

Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma

Dimopoulos M, Spencer A, Attal M, Prince HM, Harousseau JL, Dmoszynska A, San Miguel J, Hellmann A, Facon T, Foà R, Corso A, Masliak Z, Olesnyckyj M, Yu Z, Patin J, Zeldis JB, Knight RD; Multiple Myeloma (010) Study Investigators

(2007), N Engl J Med, 357(21), 2123-32

Extramedullary relapse of multiple myeloma associated with a shift in secretion from intact immunoglobulin to light chains

Dawson MA, Patil S, Spencer A

(2007), Haematologica, 92(1), 143-4

Two conserved regions within the tissue-type plasminogen activator gene promoter mediate regulation by brain-derived neurotrophic factor

Daniel PB, Lux W, Samson AL, Schleuning WD, Niego B, Weiss TW, Tjärnlund-Wolf A, Medcalf RL

(2007), FEBS J, 274(9), 2411-23

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Chaussade C, Rewcastle GW, Kendall JD, Denny WA, Cho K, Grønning LM, Chong ML, Anagnostou SH, Jackson SP, Daniele N, Shepherd PR

(2007), Biochem J, 404(3), 449-58

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