Clinical research focuses on the management and outcomes of patients with Toxic Epidermal Necrolysis (TENS); the effect of gender on mortality in burn patients; and fluid management and blood transfusion practices.
The Victorian Adult Burns Service at The Alfred provides the state-wide service for adult patients with severe burn injuries.
Clinical research topics in 2015 have included gender differences in cytokine response to burn injury, troponin levels in patients with burns and the early microbiological profile of the burn wound.
A prospective trial is under way to test the validity of a predictive equation for dressing requirements, which will contribute to state disaster response preparation and planning. Laboratory research is focused on techniques for keratinocyte culture and tissue engineering for skin substitutes.
- 3 PhD students
- 3 Masters students
Toxic Epidermal Necrolysis (TENS)
TENS is life-threatening skin condition usually caused by a reaction to drugs.Find out more
Fluid management practices in burns patients
A study in the Intensive Care Unit (ICU) of fluid resuscitation practices in burn patients demonstrated potential benefits of the use of sophisticated haemodynamic monitoring to provide clear endpoints for resuscitation.Find out more
The relationship between gender and mortality of burns patients
A study conducted by Alfred clinicians on burns patients admitted to Australian and New Zealand (ANZ)-based ICUs showed that women had more than double the risk of death compared to men.Find out more
Clinical data on all patients admitted with acute burn injury to all ANZ specialist Burns Units is collected for the BRANZ in order to monitor care and examine risk-adjusted outcomes.Find out more
Skin Tissue Culture Laboratory
The work of the Skin Tissue Culture Laboratory in evaluating the role of dermal templates in physiologic wound closure as a scaffold for tissue repair has demonstrated significant differences between different scaffolds.Find out more
ISBI Practice Guidelines for Burn Care, Part 2
ISBI Practice Guidelines Committee; Advisory Subcommittee; Steering Subcommittee
(2018), Burns, 44(7), 1617-1706
The Incidence and Significance of Raised Troponin Levels in Acute Burns
Alexander W, Schneider HG, Smith C, Cleland H
(2018), J Burn Care Res, 39(5), 729-735
Chemical burns: Diphoterine untangled
Alexander KS, Wasiak J, Cleland H
(2018), Burns, 44(4), 752-766