Mammalian Functional Genetics Unit
Our group uses transgenic mouse models and ES / iPS (embryonic stem / induced pluripotent stem) cell-based technologies to study cell fate and cellular transformation at the molecular level.
We are elucidating the role of the ZEB and SNAI family of transcription factors in normal haematopoietic stem cell differentiation and lineage commitment, as well as their roles in the development of leukaemic cancer stem cells with a focus on T-cell ALL (Goossens S et al., Nat Commun 2015).
Mammalian Functional Genetics Unit
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