Endocrinology & Diabetes research
The Department of Endocrinology and Diabetes performs clinical research in the areas of diabetes and thyroid cancer as well as basic research in diabetic complications and regulation of growth factor activity.
Professor Leon Bach (CIF) is part of a team led by Professor Mark Cooper (Baker Heart & Diabetes Institute), who were awarded $2.5 million for the JDRF/NHMRC Diabetes Complications Centre of Research Excellence for 2014-2019.
Dr Kathryn Hackman and James Lee completed PhDs on their respective topics of ‘Diabetes and lung transplantation’ and ‘Thyroid cancer and microRNA’.
- 2 PhD students
Mechanisms of diabetic complications
The high glucose levels characteristic of diabetes lead to complications such as kidney damage; however, the precise mechanisms by which this occurs is not understood.Find out more
Regulation of growth factor activity
The insulin-like growth factor (IGF) system is perturbed in many diseases, including diabetic complications and cancer. Professor Bach’s laboratory studies IGF binding protein-6 (IGFBP-6) and, particularly, its role as an IGF-II inhibitor in cancer.Find out more
New technologies for diabetes treatment
In type 1 diabetes, damage to the pancreas prevents insulin secretion to regulate glucose levels in the blood.Find out more
Diabetes burdenFind out more
What Happened to the IGF Binding Proteins?
(2018), Endocrinology, 159(2), 570-578
Differential expression of IGFBPs in Laron syndrome-derived lymphoblastoid cell lines: Potential correlation with reduced cancer incidence
Somri L, Sarfstein R, Lapkina-Gendler L, Nagaraj K, Laron Z, Bach LA, Werner H
(2018), Growth Horm IGF Res, 39, 43628
(2018), J Mol Endocrinol, 61(1), T11-28