Research publications | Alfred Health

New drugs creating new challenges in acute myeloid leukemia

Tiong, Ing S.; Wei, Andrew H.

(2019), GENE CHROMOSOME CANC, 58(12), 903-914

DOI: 10.1002/gcc.22750

Using par4 inhibition as an anti-thrombotic approach

Li, Simeng; Tarlac, Volga; Hamilton, Justin R.

(2019), INT J MOL SCI, 20(22), 5629

DOI: 10.3390/ijms20225629

Clinicopathological aspects of therapy-related acute myeloid leukemia and myelodysplastic syndrome

Chua, Chong Chyn; Fleming, Shaun; Wei, Andrew H.

(2019), BEST PRACT RES CL HA, 32(1), 3-12.

DOI: 10.1016/j.beha.2019.02.007

Venetoclax combined with low-dose cytarabine for previously untreated patients with acute myeloid leukemia

Wei, Andrew H.; Strickland, Stephen A.; Hou, Jing Zhou; Fiedler, Walter; Lin, Tara L.; Walter, Roland B.; Enjeti, Anoop; Tiong, Ing Soo; Savona, Michael; Lee, Sangmin; Chyla, Brenda; Popovic, Relja; Salem, Ahmed Hamed; Agarwal, Suresh; Xu, Tu; Fakouhi, Kaffa M.; Humerickhouse, Rod; Hong, Wan Jen; Hayslip, John; Roboz, Gail J.

(2019), J CLIN ONCOL, 37(15), 1277-1284.

DOI: 10.1200/JCO.18.01600

Polyclonal heterogeneity: The New Norm for Secondary Clinical Resistance to Targeted Monotherapy in Relapsed Leukemia?

Wei, Andrew H.; Roberts, Andrew W.

(2019), CANCER DISCOV, 9(8), 998-1000.

DOI: 10.1158/2159-8290.CD-19-0575

Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts.

Wei, Andrew; Angenendt, Linus; Röllig, Christoph; Montesinos, Pau; Martínez-Cuadrón, David; Barragán, Eva; García, Raimundo; Botella, Carmen; Martínez, Pilar; Ravandi, Farhad; Kadia, Tapan; Kantarjian, Hagop M.; Cortes, Jorge; Juliusson, Gunnar; Lazarevic, Vladimir; Höglund, Martin; Lehmann, Sören; Recher, Christian; Pigneux, Arnaud; Bertoli, Sarah; Dumas, Pierre-Yves; Dombret, Hervé; Preudhomme, Claude; Micol, Jean-Baptiste; Terré, Christine; Ráčil, Zdeněk; Novak, Jan; Zak, Pavel; Tiong, Ing Soo; Wall, Meaghan; Estey, Elihu; Shaw, Carole; Exeler, Rita; Wagenführ, Lisa

(2019), J CLIN ONCOL, 37(29), 2632-2642.

DOI: 10.1200/JCO.19.00416

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

Srivastava, Rahul; Cao, Zhipeng; Nedeva, Christina; Naim, Samara; Bachmann, Daniel; Rabachini, Tatiana; Gangoda, Lahiru; Shahi, Sanjay; Glab, Jason; Menassa, Joseph; Osellame, Laura; Nelson, Tao; Fernandez-Marrero, Yuniel; Brown, Fiona; Wei, Andrew; Ke, Francine; O'Reilly, Lorraine; Doerflinger, Marcel; Allison, Cody; Kueh, Andrew; Ramsay, Rob; Smith, Brian J.; Mathivanan, Suresh; Kaufmann, Thomas; Puthalakath, Hamsa

(2019), P NATL ACAD SCI USA, 116(31), 15469-15474.

DOI: 10.1073/pnas.1904523116

Incorporating precision BH3 warheads into the offensive against acute myeloid leukemia

Savona, Michael R.; Wei, Andrew H.

(2019), J CLIN ONCOL, 37(21), 1785-1789.

DOI: 10.1200/JCO.19.00400

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

Goossens, Steven; Wang, Jueqiong; Tremblay, Cedric S.; De Medts, Jelle; T'sas, Sara; Nguyen, Thao; Saw, Jesslyn; Haigh, Katharina; Curtis, David J.; Van Vlierberghe, Pieter; Berx, Geert; Taghon, Tom; Haigh, Jody J.

(2019), HAEMATOLOGICA, 104(8), 1608-1616.

DOI: 10.3324/haematol.2018.207837

Blinatumomab versus chemotherapy in first salvage or in later salvage for B-cell precursor acute lymphoblastic leukemia

Dombret, Hervé; Topp, Max S.; Schuh, Andre C.; Wei, Andrew H.; Durrant, Simon; Bacon, Christopher Larry; Tran, Qui; Zimmerman, Zachary; Kantarjian, Hagop

(2019), LEUKEMIA LYMPHOMA, 60(9), 2214-2222

DOI: 10.1080/10428194.2019.1576872

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

DiNardo, Courtney D.; Pratz, Keith; Pullarkat, Vinod; Jonas, Brian A.; Arellano, Martha; Becker, Pamela S.; Frankfurt, Olga; Konopleva, Marina; Wei, Andrew H.; Kantarjian, Hagop M.; Xu, Tu; Hong, Wan Jen; Chyla, Brenda; Potluri, Jalaja; Pollyea, Daniel A.; Letai, Anthony

(2019), BLOOD, 133(1), 7-17.

DOI: 10.1182/blood-2018-08-868752

Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events

Clark, Joanne C.; Kavanagh, Deirdre M.; Watson, Stephanie; Pike, Jeremy A.; Andrews, Robert K.; Gardiner, Elizabeth E.; Poulter, Natalie S.; Hill, Stephen J.; Watson, Steve P.

(2019), THROMB HAEMOSTASIS, 119(7), 1124-1137.

DOI: 10.1055/s-0039-1688788

Utility of circulating cell-free RNA analysis for the characterization of global transcriptome profiles of multiple myeloma patients

Chen, Maoshan; Mithraprabhu, Sridurga; Ramachandran, Malarmathy; Choi, Kawa; Khong, Tiffany; Spencer, Andrew

(2019), CANCERS, 11(6), 887

DOI: 10.3390/cancers11060887

Utility of a Nurse-Led Pathway for Patients with Acute Venous Thromboembolism Discharged on Rivaroxaban

Lim, Ming Sheng; Indran, Tishya; Cummins, Anita; Bennett, Ashwini; Wood, Erica; Brown, Susan; McQuilten, Zoe; Tran, Huyen; Chan, Noel C.; Chunilal, Sanjeev

(2019), SEMIN THROMB HEMOST, 45(2), 187-195.

DOI: 10.1055/s-0038-1676320

Functional Brush Poly(2-ethyl-2-oxazine)s: Synthesis by CROP and RAFT, Thermoresponsiveness and Grafting Onto Iron Oxide Nanoparticles

Klein, Tobias; Parkin, Joshua; de Jongh, Patrick A.J.M.; Esser, Lars; Sepehrizadeh, Tara; Zheng, Gang; De Veer, Michael; Alt, Karen; Hagemeyer, Christoph E.; Haddleton, David M.; Davis, Thomas P.; Thelakkat, Mukundan; Kempe, Kristian

(2019), MACROMOL RAPID COMM, 40(10), 1800911

DOI: 10.1002/marc.201800911

Epigenetic treatment-mediated modulation of PD-L1 predicts potential therapy resistance over response markers in myeloid malignancies

Liu, Hongbin; Hu, Yunshan; Rimoldi, Rafael; Von Hagt, Chloe; Khong, Edmund W.C.; Lee, Nora; Flemming, Shaun; Spencer, Andrew; Dear, Anthony E.

(2019), ONCOL LETT, 17(2), 2543-2550.

DOI: 10.3892/ol.2018.9841

Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome

Rai, Alin; Greening, David W.; Chen, Maoshan; Xu, Rong; Ji, Hong; Simpson, Richard J.

(2019), PROTEOMICS, 19(8), 1800148

DOI: 10.1002/pmic.201800148

Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Moujalled, Donia M.; Pomilio, Giovanna; Ghiurau, Corina; Ivey, Adam; Salmon, Jessica; Rijal, Sewa; Macraild, Sarah; Zhang, Lan; Teh, Tse Chieh; Tiong, Ing Soo; Lan, Ping; Chanrion, Maia; Claperon, Audrey; Rocchetti, Francesca; Zichi, Adrien; Kraus-Berthier, Laurence; Wang, Youzhen; Halilovic, Ensar; Morris, Erick; Colland, Frédéric; Segal, David; Huang, David; Roberts, Andrew W.; Maragno, Ana Leticia; Lessene, Guillaume; Geneste, Olivier; Wei, Andrew H.

(2019), LEUKEMIA, 33(a), 905-917.

DOI: 10.1038/s41375-018-0261-3

Monitoring tumour burden and therapeutic response through analysis of circulating tumour DNA and extracellular RNA in multiple myeloma patients

Mithraprabhu, Sridurga; Morley, Rachel; Khong, Tiffany; Kalff, Anna; Bergin, Krystal; Hocking, Jay; Savvidou, Ioanna; Bowen, Kathryn M.; Ramachandran, Malarmathy; Choi, Kawa; Wong, Boris Ka Leong; Reynolds, John; Spencer, Andrew

(2019), LEUKEMIA, 33(8), 2022-2033.

DOI: 10.1038/s41375-019-0469-x

DNA-repair gene mutations are highly prevalent in circulating tumour dna from multiple myeloma patients

Mithraprabhu, Sridurga; Hocking, Jay; Ramachandran, Malarmathy; Choi, Kawa; Klarica, Daniela; Khong, Tiffany; Reynolds, John; Spencer, Andrew

(2019), CANCERS, 11(7), 917

DOI: 10.3390/cancers11070917