Research publications | Alfred Health

MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia

Brown, Fiona C.; Still, Eric; Koche, Richard P.; Yim, Christina Y.; Takao, Sumiko; Cifani, Paolo; Reed, Casie; Gunasekera, Shehana; Ficarro, Scott B.; Romanienko, Peter; Mark, Willie; McCarthy, Craig; de Stanchina, Elisa; Gonen, Mithat; Seshan, Venkatraman; Bhola, Patrick; O’Donnell, Conor; Spitzer, Barbara; Stutzke, Crystal; Lavall»e, Vincent Philippe; H»bert, Jos»e; Krivtsov, Andrei V.; Melnick, Ari; Paietta, Elisabeth M.; Tallman, Martin S.; Letai, Anthony; Sauvageau, Guy; Pouliot, Gayle; Levine, Ross; Marto, Jarrod A.; Armstrong, Scott A.; Kentsis, Alex

(2018), Cancer Discov, 8(4), 478-497

DOI: 10.1158/2159-8290.CD-17-1271

The Canonical Wnt/β-catenin Pathway as a Therapeutic Target in Multiple Myeloma

Savvidou, Ioanna; Khong, Tiffany; Spencer, Andrew; Alt, Karen Maria

(2018), ARCH MED RES, 6(7), 43480

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tremblay, Cedric; Saw, Jesslyn; Chiu, Sung Kai; Wong, Nicholas C.; Tsyganov, Kirill; Ghotb, Sarah; Graham, Alison N; Yan, Feng; Guirguis, Andrew; Sonderegger, Stefan; Lee, Nicole; Kalitsis, Paul; Reynolds, John; Ting, Stephen; Powell, David; Jane, Stephen; Curtis, David

(2018), Nat Commun, 9(1), 3535

DOI: 10.1038/s41467-018-06021-7

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Bouhy, Delphine; Juneja, Manisha; Katona, Istvan; Holmgren, Anne; Asselbergh, Bob; De Winter, Vicky; Hochepied, Tino; Goossens, Steven; Haigh, Jody J.; Libert, Claude; Ceuterick-de Groote, Chantal; Irobi, Joy; Weis, Joachim; Timmerman, Vincent

(2018), Acta Neuropathol, 135(1), 131-148

DOI: 10.1007/s00401-017-1756-0

Contemporary analysis of functional immune recovery to opportunistic and vaccine-preventable infections after allogeneic haemopoietic stem cell transplantation

De Silva, Harini; Ffrench, Rosemary Ann; Korem, Maya; Orlowski-Oliver, Eva; Curtis, David John; Spencer, Andrew; Avery, Sharon; Patil, Sushrut; Morrissey, Catherine Orla

(2018), Clin Transl Immunology, 7(10), e1040

DOI: 10.1002/cti2.1040

A comparison of global coagulation assays between normal controls and patients with thrombocytopenia

Lim, Hui Yin; Leung, Patrick; Manitta, Vanessa; Nandurkar, Harshal; Ho, Prahlad

(2018), INT J LAB HEMATOL, 41(2), 184-191

DOI: 10.1111/ijlh.12941

Perinatal lethality of Par4–/– mice delivered by primiparous dams reveals spontaneous bleeding in mice without platelet thrombin receptor function

French, Shauna L.; Hamilton, Justin R.

(2018), Platelets, 29(2), 196-198

DOI: 10.1080/09537104.2017.1349310

Thrombin generation estimates the anticoagulation effect of direct oral anticoagulants with significant interindividual variability observed

Rigano, Joseph; Ng, Cheryl; Nandurkar, Harshal Hanumant; Ho, Prahlad

(2018), Blood Coagul Fibrinolysis, 29(2), 148-154

DOI: 10.1097/MBC.0000000000000678

An evaluation of global coagulation assays in myeloproliferative neoplasm

Lim, Hui Y.; Ng, Cheryl; Rigano, Joseph; Tacey, Mark Alan; Donnan, Geoffrey; Nandurkar, Harshal Hanumant; Ho, Prahlad Wei Soon

(2018), Blood Coagul Fibrinolysis, 29(3), 300-306

DOI: 10.1097/MBC.0000000000000724

Carfilzomib–dexamethasone versus subcutaneous or intravenous bortezomib in relapsed or refractory multiple myeloma

Goldschmidt, Hartmut; Moreau, Philippe; Ludwig, Heinz; Niesvizky, Ruben; Chng, Wee Joo; Joshua, Douglas; Weisel, Katja; Spencer, Andrew; Orlowski, Robert Z.; Feng, Shibao; Iskander, Karim S.; Dimopoulos, Meletios A.

(2018), Leuk Lymphoma, 59(6), 1364-1374

DOI: 10.1080/10428194.2017.1376743

Mechanisms of receptor shedding in platelets

Montague, Samantha J.; Andrews, Robert K.; Gardiner, Elizabeth E.

(2018), Blood, 132(24), 2535-2545

DOI: 10.1182/blood-2018-03-742668

Psammomys obesus

Chaudhary, Rajneesh; Walder, Ken R.; Hagemeyer, Christoph E.; Kanwar, Jagat R.

(2018), Curr Atheroscler Rep, 20(9), 46

DOI: 10.1007/s11883-018-0746-6

Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4–heparin antibodies in heparin-induced thromobocytopenia

Wines, B. D.; Tan, C. W.; Duncan, E.; McRae, S.; Baker, R. I.; Andrews, R. K.; Esparon, S.; Gardiner, E. E.; Hogarth, P. M.

(2018), J Thromb Haemost, 16(12), 2520-2525

DOI: 10.1111/jth.14306

Daratumumab plus bortezomib and dexamethasone versus bortezomib and dexamethasone in relapsed or refractory multiple myeloma

Spencer, Andrew; Lentzsch, Suzanne; Weisel, Katja; Avet-Loiseau, Herv»; Mark, Tomer M.; Spicka, Ivan; Masszi, Tamas; Lauri, Birgitta; Levin, Mark David; Bosi, Alberto; Hungria, Vania; Cavo, Michele; Lee, Je Jung; Nooka, Ajay K.; Quach, Hang; Lee, Cindy; Barreto, Wolney; Corradini, Paolo; Min, Chang Ki; Scott, Emma C.; Chanan-Khan, Asher A.; Horvath, Noemi; Capra, Marcelo; Beksac, Meral; Ovilla, Roberto; Jo, Jae Cheol; Shin, Ho Jin; Sonneveld, Pieter; Soong, David; Casneuf, Tineke; Chiu, Christopher; Amin, Himal; Qi, Ming; Thiyagarajah, Piruntha; Sasser, A. Kate; Schecter, Jordan M.; Mateos, Maria Victoria

(2018), Haematologica, 103(12), 2079-2087

DOI: 10.3324/haematol.2018.194118

A phase 1 clinical trial evaluating marizomib, pomalidomide and low-dose dexamethasone in relapsed and refractory multiple myeloma (NPI-0052-107)

Spencer, Andrew; Harrison, Simon; Zonder, Jeffrey; Badros, Ashraf; Laubach, Jacob; Bergin, Krystal; Khot, Amit; Zimmerman, Todd; Chauhan, Dharminder; Levin, Nancy; MacLaren, Ann; Reich, Steven D.; Trikha, Mohit; Richardson, Paul

(2018), Br J Haematol, 180(1), 41-51

DOI: 10.1111/bjh.14987

Considerations for pre-transfusion immunohaematology testing in patients receiving the anti-CD38 monoclonal antibody daratumumab for the treatment of multiple myeloma

Quach, Hang; Benson, Simon; Haysom, Helen; Wilkes, Anne Marie; Zacher, Nicole; Cole-Sinclair, Merrole; Miles Prince, Henry; Mollee, Peter; Spencer, Andrew; Joy Ho, Phoebe; Harrison, Simon J.; Lee, Cindy; Augustson, Bradley; Daly, James

(2018), Intern Med J, 48(2), 210-220

DOI: 10.1111/imj.13707

NLRP3 regulates platelet integrin ±IIbβ3 outside-in signaling, hemostasis and arterial thrombosis

Qiao, Jianlin; Wu, Xiaoqing; Luo, Qi; Wei, Guangyu; Xu, Mengdi; Wu, Yulu; Liu, Yun; Li, Xiaoqian; Zi, Jie; Ju, Wen; Fu, Lin; Chen, Chong; Wu, Qingyun; Zhu, Shengyun; Qi, Kunming; Li, Depeng; Li, Zhenyu; Andrews, Robert K.; Zeng, Lingyu; Gardiner, Elizabeth E.; Xu, Kailin

(2018), Haematologica, 103(9), 1568-1576

DOI: 10.3324/haematol.2018.191700

Soluble GPVI is elevated in injured patients

Montague, Samantha J.; Delierneux, C»line; Lecut, Christelle; Layios, Nathalie; Dinsdale, Robert J.; Lee, Christine S.M.; Poulter, Natalie S.; Andrews, Robert K.; Hampson, Peter; Wearn, Christopher M.; Maes, Nathalie; Bishop, Jonathan; Bamford, Amy; Gardiner, Chris; Lee, Woei Ming; Iqbal, Tariq; Moiemen, Naiem; Watson, Steve P.; Oury, C»cile; Harrison, Paul; Gardiner, Elizabeth E.

(2018), Blood Adv, 2(3), 240-251

DOI: 10.1182/bloodadvances.2017011171

Characterization of Tfrc-mutant mice with microcytic phenotypes

Conway, Ashlee Jade; Brown, Fiona C.; Rank, Gerhard; Kile, Benjamin T.; Morton, Craig J.; Jane, Stephen M.; Curtis, David J.

(2018), Blood Adv, 2(5), 1914-1922

DOI: 10.1182/bloodadvances.2018018820

A novel role for Lyl1 in primitive erythropoiesis

Chiu, Sung Kai; Saw, Jesslyn Mei Yoong; Huang, Yizhou; Sonderegger, Stefan Eugen; Wong, Nicholas Chau Lun; Powell, David Richard; Beck, Dominic; Pimanda, John; Tremblay, Cedric; Curtis, David John

(2018), Development, 145(19), dev162990

DOI: 10.1242/dev.162990