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Alfred Health research outcomes are published in a wide range of peer reviewed journals.
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Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis
Green TN, Hamilton JR, Morel-Kopp MC, Zheng Z, Chen TT, Hearn JI, Sun PP, Flanagan JU, Young D, Barber PA, During MJ, Ward CM, Kalev-Zylinska ML
(2017), Platelets, 28(8), 799-811
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia
Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ
(2017), Blood, 129(8), 981-90
tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS
Fredriksson L, Lawrence DA, Medcalf RL
(2017), Semin Thromb Hemost, 43(2), 154-68
Plasmin: A Modulator of Immune Function
Draxler DF, Sashindranath M, Medcalf RL
(2017), Semin Thromb Hemost, 43(2), 143-53
Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma
Nair AP, Walker P, Kalff A, Bergin K, Hocking J, Avery S, Curtis DJ, Patil S, Das T, Klarica D, Morgan S, Muirhead J, Gorniak M, Reynolds J, Spencer A
(2017), Bone Marrow Transplant, 52(6), 839-45
DOI: 10.1038/bmt.2017.37
Elevated ΔNp63Α Levels Facilitate Epidermal and Biliary Oncogenic Transformation
Devos M, Gilbert B, Denecker G, Leurs K, Mc Guire C, Lemeire K, Hochepied T, Vuylsteke M, Lambert J, Van Den Broecke C, Libbrecht L, Haigh J, Berx G, Lippens S, Vandenabeele P, Declercq W
(2017), J Invest Dermatol, 137(2), 494-505
Venous thromboembolism management in Northeast Melbourne: how does it compare to international guidelines and data?
Lim HY, Chua CC, Tacey M, Sleeman M, Donnan G, Nandurkar H, Ho P
(2017), Intern Med J, 47(9), 1034-42
DOI: 10.1111/imj.13525
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia
Powell JA, Lewis AC, Zhu W, Toubia J, Pitman MR, Wallington-Beddoe CT, Moretti PA, Iarossi D, Samaraweera SE, Cummings N, Ramshaw HS, Thomas D, Wei AH, Lopez AF, D'Andrea RJ, Lewis ID, Pitson SM
(2017), Blood, 129(6), 771-82
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population
Hein N, Cameron DP, Hannan KM, Nguyen NN, Fong CY, Sornkom J, Wall M, Pavy M, Cullinane C, Diesch J, Devlin JR, George AJ, Sanij E, Quin J, Poortinga G, Verbrugge I, Baker A, Drygin D, Harrison SJ, Rozario JD, Powell JA, Pitson SM, Zuber J, Johnstone RW, Dawson MA, Guthridge MA, Wei A, McArthur GA, Pearson RB, Hannan RD
(2017), Blood, 129(21), 2882-95
Loss of Dynamin 2 GTPase function results in microcytic anaemia
Brown FC, Collett M, Tremblay CS, Rank G, De Camilli P, Booth CJ, Bitoun M, Robinson PJ, Kile BT, Jane SM, Curtis DJ
(2017), Br J Haematol, 178(4), 616-28
DOI: 10.1111/bjh.14709
Clustering of glycoproteinÜVI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets
Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM
(2017), J Thromb Haemost, 15(3), 549-64
DOI: 10.1111/jth.13613
The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling
Li J, Riedt T, Goossens S, Carrillo GarcÃa C, Szczepanski S, Brandes M, Pieters T, Dobrosch L, G?tgemann I, Farla N, Radaelli E, Hulpiau P, Mallela N, Fràhlich H, La Starza R, Matteucci C, Chen T, Brossart P, Mecucci C, Huylebroeck D, Haigh JJ, Janzen V
(2017), Blood, 129(4), 460-72
ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease
Kim K, Li J, Barazia A, Tseng A, Youn SW, Abbadessa G, Yu Y, Schwartz B, Andrews RK, Gordeuk VR, Cho J
(2017), Haematologica, 102(2), 246-59
Retrospective evaluation of venous thromboembolism: are all transient provoking events the same?
Chua CC, Lim HY, Tacey M, Nandurkar H, Ho P
(2017), Eur J Haematol, 99(1), 18-26
DOI: 10.1111/ejh.12884
Class II phosphoinositide 3-kinases as novel drug targets
Falasca M, Hamilton JR, Selvadurai M, Sundaram K, Adamska A, Thompson PE
(2017), J Med Chem, 60(1), 47-65
Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells
Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld FG, Goossens S, Haigh JJ, Huylebroeck D
(2017), Stem Cells, 35(3), 611-25
DOI: 10.1002/stem.2521
Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a
Jackson JT, Shields BJ, Shi W, Di Rago L, Metcalf D, Nicola NA, McCormack MP
(2017), Stem Cells, 35(8), 1948-57
DOI: 10.1002/stem.2648
LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage
Niego B, Broughton BRS, Ho H, Sobey CG, Medcalf RL
(2017), Fluids Barriers CNS, 14(1), 33
TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway
Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, Liddell JR, White AR
(2017), Hum Mol Genet, 26(9), 1732-46
DOI: 10.1093/hmg/ddx093
Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
Pieters, Tim; Haenebalcke, Lieven; Bruneel, Kenneth; Vandamme, Niels; Hochepied, Tino; van Hengel, Jolanda; Wirth, Dagmar; Berx, Geert; Haigh, Jody J; Van Roy, Frans; Goossens, Steven
(2017), J Vis Exp, 122,
DOI: 10.3791/55575