Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Green TN, Hamilton JR, Morel-Kopp MC, Zheng Z, Chen TT, Hearn JI, Sun PP, Flanagan JU, Young D, Barber PA, During MJ, Ward CM, Kalev-Zylinska ML

(2017), Platelets, 28(8), 799-811

DOI: 10.1080/09537104.2017.1280149

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ

(2017), Blood, 129(8), 981-90

DOI: 10.1182/blood-2016-06-721191

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS

Fredriksson L, Lawrence DA, Medcalf RL

(2017), Semin Thromb Hemost, 43(2), 154-68

DOI: 10.1055/s-0036-1586229

Plasmin: A Modulator of Immune Function

Draxler DF, Sashindranath M, Medcalf RL

(2017), Semin Thromb Hemost, 43(2), 143-53

DOI: 10.1055/s-0036-1586227

Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma

Nair AP, Walker P, Kalff A, Bergin K, Hocking J, Avery S, Curtis DJ, Patil S, Das T, Klarica D, Morgan S, Muirhead J, Gorniak M, Reynolds J, Spencer A

(2017), Bone Marrow Transplant, 52(6), 839-45

DOI: 10.1038/bmt.2017.37

Elevated ΔNp63Α Levels Facilitate Epidermal and Biliary Oncogenic Transformation

Devos M, Gilbert B, Denecker G, Leurs K, Mc Guire C, Lemeire K, Hochepied T, Vuylsteke M, Lambert J, Van Den Broecke C, Libbrecht L, Haigh J, Berx G, Lippens S, Vandenabeele P, Declercq W

(2017), J Invest Dermatol, 137(2), 494-505

DOI: 10.1016/j.jid.2016.09.026

Venous thromboembolism management in Northeast Melbourne: how does it compare to international guidelines and data?

Lim HY, Chua CC, Tacey M, Sleeman M, Donnan G, Nandurkar H, Ho P

(2017), Intern Med J, 47(9), 1034-42

DOI: 10.1111/imj.13525

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Powell JA, Lewis AC, Zhu W, Toubia J, Pitman MR, Wallington-Beddoe CT, Moretti PA, Iarossi D, Samaraweera SE, Cummings N, Ramshaw HS, Thomas D, Wei AH, Lopez AF, D'Andrea RJ, Lewis ID, Pitson SM

(2017), Blood, 129(6), 771-82

DOI: 10.1182/blood-2016-06-720433

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Hein N, Cameron DP, Hannan KM, Nguyen NN, Fong CY, Sornkom J, Wall M, Pavy M, Cullinane C, Diesch J, Devlin JR, George AJ, Sanij E, Quin J, Poortinga G, Verbrugge I, Baker A, Drygin D, Harrison SJ, Rozario JD, Powell JA, Pitson SM, Zuber J, Johnstone RW, Dawson MA, Guthridge MA, Wei A, McArthur GA, Pearson RB, Hannan RD

(2017), Blood, 129(21), 2882-95

DOI: 10.1182/blood-2016-05-718171

Loss of Dynamin 2 GTPase function results in microcytic anaemia

Brown FC, Collett M, Tremblay CS, Rank G, De Camilli P, Booth CJ, Bitoun M, Robinson PJ, Kile BT, Jane SM, Curtis DJ

(2017), Br J Haematol, 178(4), 616-28

DOI: 10.1111/bjh.14709

Clustering of glycoproteinÜVI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM

(2017), J Thromb Haemost, 15(3), 549-64

DOI: 10.1111/jth.13613

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Li J, Riedt T, Goossens S, Carrillo GarcÃa C, Szczepanski S, Brandes M, Pieters T, Dobrosch L, G?tgemann I, Farla N, Radaelli E, Hulpiau P, Mallela N, Fràhlich H, La Starza R, Matteucci C, Chen T, Brossart P, Mecucci C, Huylebroeck D, Haigh JJ, Janzen V

(2017), Blood, 129(4), 460-72

DOI: 10.1182/blood-2016-05-714659

ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease

Kim K, Li J, Barazia A, Tseng A, Youn SW, Abbadessa G, Yu Y, Schwartz B, Andrews RK, Gordeuk VR, Cho J

(2017), Haematologica, 102(2), 246-59

DOI: 10.3324/haematol.2016.151159

Retrospective evaluation of venous thromboembolism: are all transient provoking events the same?

Chua CC, Lim HY, Tacey M, Nandurkar H, Ho P

(2017), Eur J Haematol, 99(1), 18-26

DOI: 10.1111/ejh.12884

Class II phosphoinositide 3-kinases as novel drug targets

Falasca M, Hamilton JR, Selvadurai M, Sundaram K, Adamska A, Thompson PE

(2017), J Med Chem, 60(1), 47-65

DOI: 10.1021/acs.jmedchem.6b00963

Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells

Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld FG, Goossens S, Haigh JJ, Huylebroeck D

(2017), Stem Cells, 35(3), 611-25

DOI: 10.1002/stem.2521

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Jackson JT, Shields BJ, Shi W, Di Rago L, Metcalf D, Nicola NA, McCormack MP

(2017), Stem Cells, 35(8), 1948-57

DOI: 10.1002/stem.2648

LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage

Niego B, Broughton BRS, Ho H, Sobey CG, Medcalf RL

(2017), Fluids Barriers CNS, 14(1), 33

DOI: 10.1186/s12987-017-0081-2

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, Liddell JR, White AR

(2017), Hum Mol Genet, 26(9), 1732-46

DOI: 10.1093/hmg/ddx093

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange

Pieters, Tim; Haenebalcke, Lieven; Bruneel, Kenneth; Vandamme, Niels; Hochepied, Tino; van Hengel, Jolanda; Wirth, Dagmar; Berx, Geert; Haigh, Jody J; Van Roy, Frans; Goossens, Steven

(2017), J Vis Exp, 122,

DOI: 10.3791/55575

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