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Alfred Health research outcomes are published in a wide range of peer reviewed journals.
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p120 catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification
Pieters T, Goossens S, Haenebalcke L, Andries V, Stryjewska A, De Rycke R, Lemeire K, Hochepied T, Huylebroeck D, Berx G, Stemmler MP, Wirth D, Haigh JJ, van Hengel J, van Roy F
(2016), PLoS Genet, 12(8),
Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability
Petitjean C, Setiabakti NM, Mountford JK, Arthur JF, Ellis S, Hamilton JR
(2016), Platelets, 27(5),
PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia
Pang SH, Minnich M, Gangatirkar P, Zheng Z, Ebert A, Song G, Dickins RA, Corcoran LM, Mullighan CG, Busslinger M, Huntington ND, Nutt SL, Carotta S
(2016), Leukemia, 30(6),
Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros
Ng ES, Azzola L, Bruveris FF, Calvanese V, Phipson B, Vlahos K, Hirst C, Jokubaitis VJ, Yu QC, Maksimovic J, Liebscher S, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock DN, Nilsson SK, Saffery R, Schenke-Lay
(2016), Nat Biotechnol, 34(11),
Epigenetic regulation of miRNA-124 and multiple downstream targets is associated with treatment response in myeloid malignancies
Liu H, Pattie P, Chandrasekara S, Spencer A, Dear AE
(2016), Oncol Lett, 12(3),
Ten years of cerebral venous thrombosis: male gender and myeloproliferative neoplasm is associated with thrombotic recurrence in unprovoked events
Lim HY, Ng C, Donnan G, Nandurkar H, Ho P
(2016), J Thromb Thrombolysis, 42(3),
Mitochondrial DNA plasticity is an essential inducer of tumorigenesis
Lee WT, Cain JE, Cuddihy A, Johnson J, Dickinson A, Yeung KY, Kumar B, Johns TG, Watkins DN, Spencer A, St John JC
(2016), Cell Death Discov, 2,
Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse
Larsson P, Alwis I, Niego B, Sashindranath M, Fogelstrand P, Wu MC, Glise L, Magnusson M, Daglas M, Bergh N, Jackson SP, Medcalf RL, Jern S
(2016), J Thromb Haemost, 14(12),
PTP1B deficiency enables the ability of a high-fat diet to drive the invasive character of PTEN-deficient prostate cancers
Labbé DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, Sirois J, Haigh JJ, Bégin LR, Trotman LC, Paquet M, Tremblay ML
(2016), Cancer Res, 76(11),
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurn
(2016), Nature, 538(7626),
Ablation of type-1 IFN signaling in hematopoietic cells confers protection following traumatic brain injury
Karve IP, Zhang M, Habgood M, Frugier T, Brody KM, Sashindranath M, Ek CJ, Chappaz S, Kile BT, Wright D, Wang H, Johnston L, Daglas M, Ates RC, Medcalf RL, Taylor JM, Crack PJ
(2016), eNeuro, 3(1),
GAPTrap: a simple expression system for pluripotent stem cells and their derivatives
Kao T, Labonne T, Niclis JC, Chaurasia R, Lokmic Z, Qian E, Bruveris FF, Howden SE, Motazedian A, Schiesser JV, Costa M, Sourris K, Ng E, Anderson D, Giudice A, Farlie P, Cheung M, Lamande SR, Penington AJ, Parish CL, Thomson LH, Rafii A, Elliott DA, Elef
(2016), Stem Cell Rep, 7(3),
Heavy menstrual bleeding and dysmenorrhea are improved by magentic resonance guided focused ultrasound surgery (MRgFUS) of adenomyosis
Jayaram R, Subbarayan K, Mithraprabhu S, Govindarajan M
(2016), Fertil Res Pract, 2,
Retrospective review on isolated distal deep vein thrombosis (IDDVT) - a benign entity or not?
Ho P, Lim HY, Chua CC, Sleeman M, Tacey M, Donnan G, Nandurkar H
(2016), Thromb Res, 142,
Molecular imaging of activated platelets allows the detection of pulmonary embolism with magnetic resonance imaging
Heidt T, Ehrismann S, HÖvener JB, Neudorfer I, Hilgendorf I, Reisert M, Hagemeyer CE, Zirlik A, ReinÖhl J, Bode C, Peter K, von Elverfeldt D, von Zur Muhlen C
(2016), Sci Rep, 6,
PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia
Guirguis AA, Slape CI, Failla LM, Saw J, Tremblay CS, Powell DR, Rossello F, Wei A, Strasser A, Curtis DJ
(2016), Cell Death Differ, 23(6),
Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia
Ghisi M, Kats L, Masson F, Li J, Kratina T, Vidacs E, Gilan O, Doyle MA, Newbold A, Bolden JE, Fairfax KA, de Graaf CA, Firth M, Zuber J, Dickins RA, Corcoran LM, Dawson MA, Belz GT, Johnstone RW
(2016), Cancer Cell, 30(1),
Platelet and erythrocyte sources of s1p are redundant for vascular development and homeostasis, but both rendered essential after plasma s1p depletion in anaphylactic shock
Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E
(2016), Circ Res, 119(8),
Humanizing the protease-activated receptor (par) expression profile in mouse platelets by knocking par1 into the par3 locus reveals par1 expression is not tolerated in mouse platelets
French SL, Paramitha AC, Moon MJ, Dickins RA, Hamilton JR
(2016), PLoS One, 11(10),
Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood
French SL, Arthur JF, Lee H, Nesbitt WS, Andrews RK, Gardiner EE, Hamilton JR
(2016), J Thromb Haemost, 14(8),