Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Genomic characterisation of EΜ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Lefebure M, Tothill RW, Kruse E, Hawkins ED, Shortt J, Matthews GM, Gregory GP, Martin BP, Kelly MJ, Todorovski I, Doyle MA, Lupat R, Li J, Schroeder J, Wall M, Craig S, Poortinga G, Cameron D, Bywater M, Kats L, Gearhart MD, Bardwell VJ, Dickins RA, Hannan RD, Papenfuss AT, Johnstone RW

(2017), Nat Commun, 8, 14581

DOI: 10.1038/ncomms14581

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

Witkowski MT, Hu Y, Roberts KG, Boer JM, McKenzie MD, Liu GJ, Le Grice OD, Tremblay CS, Ghisi M, Willson TA, Horstmann MA, Aifantis I, Cimmino L, Frietze S, den Boer ML, Mullighan CG, Smyth GK, Dickins RA

(2017), J Exp Med, 214(3), 773-9

DOI: 10.1084/jem.20160048

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

Ginn SL, Hallwirth CV, Liao SH, Teber ET, Arthur JW, Wu J, Lee HC, Tay SS, Hu M, Reddel RR, McCormack MP, Thrasher AJ, Cavazzana M, Alexander SI, Alexander IE

(2017), Mol Ther Nucleic Acids, 6, 1-14

DOI: 10.1016/j.omtn.2016.11.011

A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood

Draxler DF, Madondo MT, Hanafi G, Plebanski M, Medcalf RL

(2017), Cytom Part A, 91(4), 336-50

DOI: 10.1002/cyto.a.23080

Significant age, race and gender differences in global coagulation assays parameters in the normal population

Ho P, Ng C, Rigano J, Tacey M, Smith C, Donnan G, Nandurkar H

(2017), Thromb Res, 154, 80-3

DOI: 10.1016/j.thromres.2017.04.009

High rates of potentially infectious exposures between immunocompromised patients and their companion animals: an unmet need for education. Gurry GA, Campion V, Premawardena C, Woolley I, Shortt J, Bowden DK, Kaplan Z, Dendle C

Gurry GA, Campion V, Premawardena C, Woolley I, Shortt J, Bowden DK, Kaplan Z, Dendle C

(2017), Intern Med J, 7(3), 333-5

DOI: 10.1111/imj.13361

Specification of neurotransmitter identity by Tal1 in thalamic nuclei

Lee B, Lee M, Song S, Loi LD, Lam DT, Yoon J, Baek K, Curtis DJ, Jeong Y

(2017), Dev Dyn, 246(10), 749-58

DOI: 10.1002/dvdy.24546

Fibrinolysis: Biochemistry, Clinical Aspects, and Therapeutic Potential

Kwaan H, Lisman T, Medcalf RL

(2017), Semin Thromb Hemost, 43(2), 113-4

DOI: 10.1055/s-0036-1598000

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Green TN, Hamilton JR, Morel-Kopp MC, Zheng Z, Chen TT, Hearn JI, Sun PP, Flanagan JU, Young D, Barber PA, During MJ, Ward CM, Kalev-Zylinska ML

(2017), Platelets, 28(8), 799-811

DOI: 10.1080/09537104.2017.1280149

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ

(2017), Blood, 129(8), 981-90

DOI: 10.1182/blood-2016-06-721191

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS

Fredriksson L, Lawrence DA, Medcalf RL

(2017), Semin Thromb Hemost, 43(2), 154-68

DOI: 10.1055/s-0036-1586229

Plasmin: A Modulator of Immune Function

Draxler DF, Sashindranath M, Medcalf RL

(2017), Semin Thromb Hemost, 43(2), 143-53

DOI: 10.1055/s-0036-1586227

Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma

Nair AP, Walker P, Kalff A, Bergin K, Hocking J, Avery S, Curtis DJ, Patil S, Das T, Klarica D, Morgan S, Muirhead J, Gorniak M, Reynolds J, Spencer A

(2017), Bone Marrow Transplant, 52(6), 839-45

DOI: 10.1038/bmt.2017.37

Elevated ΔNp63Α Levels Facilitate Epidermal and Biliary Oncogenic Transformation

Devos M, Gilbert B, Denecker G, Leurs K, Mc Guire C, Lemeire K, Hochepied T, Vuylsteke M, Lambert J, Van Den Broecke C, Libbrecht L, Haigh J, Berx G, Lippens S, Vandenabeele P, Declercq W

(2017), J Invest Dermatol, 137(2), 494-505

DOI: 10.1016/j.jid.2016.09.026

Venous thromboembolism management in Northeast Melbourne: how does it compare to international guidelines and data?

Lim HY, Chua CC, Tacey M, Sleeman M, Donnan G, Nandurkar H, Ho P

(2017), Intern Med J, 47(9), 1034-42

DOI: 10.1111/imj.13525

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Powell JA, Lewis AC, Zhu W, Toubia J, Pitman MR, Wallington-Beddoe CT, Moretti PA, Iarossi D, Samaraweera SE, Cummings N, Ramshaw HS, Thomas D, Wei AH, Lopez AF, D'Andrea RJ, Lewis ID, Pitson SM

(2017), Blood, 129(6), 771-82

DOI: 10.1182/blood-2016-06-720433

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Hein N, Cameron DP, Hannan KM, Nguyen NN, Fong CY, Sornkom J, Wall M, Pavy M, Cullinane C, Diesch J, Devlin JR, George AJ, Sanij E, Quin J, Poortinga G, Verbrugge I, Baker A, Drygin D, Harrison SJ, Rozario JD, Powell JA, Pitson SM, Zuber J, Johnstone RW, Dawson MA, Guthridge MA, Wei A, McArthur GA, Pearson RB, Hannan RD

(2017), Blood, 129(21), 2882-95

DOI: 10.1182/blood-2016-05-718171

Loss of Dynamin 2 GTPase function results in microcytic anaemia

Brown FC, Collett M, Tremblay CS, Rank G, De Camilli P, Booth CJ, Bitoun M, Robinson PJ, Kile BT, Jane SM, Curtis DJ

(2017), Br J Haematol, 178(4), 616-28

DOI: 10.1111/bjh.14709

Clustering of glycoproteinÜVI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM

(2017), J Thromb Haemost, 15(3), 549-64

DOI: 10.1111/jth.13613

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Li J, Riedt T, Goossens S, Carrillo GarcÃa C, Szczepanski S, Brandes M, Pieters T, Dobrosch L, G?tgemann I, Farla N, Radaelli E, Hulpiau P, Mallela N, Fràhlich H, La Starza R, Matteucci C, Chen T, Brossart P, Mecucci C, Huylebroeck D, Haigh JJ, Janzen V

(2017), Blood, 129(4), 460-72

DOI: 10.1182/blood-2016-05-714659

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