Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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A-Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets

Facey A, Pinar I, Arthur JF, Qiao J, Jing J, Mado B, Carberry J, Andrews RK, Gardiner EE

(2016), Biochemistry, 55(8),

Targeting p38 or MK2 enhances the anti-leukemic activity of Smac-mimetics

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M,

(2016), Cancer Cell, 29(2),

Profiling clinical platelet and plasma use to inform blood supply and contingency planning: PUPPY, the prospective utilization of platelets and plasma study

Fedele PL, Polizzotto MN, Grigoriadis G, Waters N, Comande M, Borosak M, Portbury D, Wood EM

(2016), Transfusion, 56(10),

Multicentre randomised placebo-controlled trial of oral anticoagulation with apixaban in systemic sclerosis-related pulmonary arterial hypertension: the SPHInX study protocol

Calderone A, Stevens W, Prior D, Nandurkar H, Gabbay E, Proudman SM, Williams T, Celermajer D, Sahhar J, Wong PK, Thakkar V, Dwyer N, Wrobel J, Chin W, Liew D, Staples M, Buchbinder R, Nikpour M

(2016), BMJ Open, 6(12),

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J

(2016), Sci Transl Med, 8(339),

Isavuconazole as salvage therapy for mucormycosis

Graves R, Morrissey CO, Wei A, Coutsouvelis J, Ellis S, Pham A, Gooi J, Ananda-Rajah M

(2016), Med Mycol Case Rep, 11,

Primary antifungal prophylaxis in adult patients with acute lymphoblastic leukaemia: a multicentre audit

Doan TN, Kirkpatrick CMJ, Walker P, Slavin M, Ananda-Rajah M, Morissey CO, Urbancic K, Grigg A, Spencer A, Szer J, Seymour J, Kong DCM

(2016), J Antimicrob Chemother, 71(2),

Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma

Seggewiss-Bernhardt R, Bargou RC, Goh YT, Stewart AK, Spencer A, Alegre A, Bladé J, Ottmann OG, Fernandez-Ibarra C, Lu H, Pain S, Akimov M, Iyer SP

(2015), Cancer, 121(13), 2185-92

The residual risk of transfusion-transmitted cytomegalovirus infection associated with leucodepleted blood components

Seed CR, Wong J, Polizzotto MN, Faddy H, Keller AJ, Pink J

(2015), Vox Sang, 109(1), 11-7

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D

(2015), Proc Natl Acad Sci USA, 112(5), 1535-40

A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia

Kipps TJ, Eradat H, Grosicki S, Catalano J, Cosolo W, Dyagil IS, Yalamanchili S, Chai A, Sahasranaman S, Punnoose E, Hurst D, Pylypenko H

(2015), Leuk Lymphoma, 56(10), 2826-33

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

Dimopoulos MA, Weisel KC, Song KW, Delforge M, Karlin L, Goldschmidt H, Moreau P, Banos A, Oriol A, Garderet L, Cavo M, Ivanova V, Alegre A, Martinez-Lopez J, Chen C, Spencer A, Knop S, Bahlis NJ, Renner C, Yu X, Hong K, Sternas L, Jacques C, Zaki MH, San Miguel JF

(2015), Haematologica, 100(10), 1327-33

An analysis of the thromboembolic outcomes of 2472 splenectomized individuals

Dendle C, Spelman T, Sundararajan V, Chunilal S, Woolley I

(2015), Blood, 125(10), 1681-2

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Van Overbeke W, Wongsantichon J, Everaert I, Verhelle A, Zwaenepoel O, Loonchanta A, Burtnick LD, De Ganck A, Hochepied T, Haigh J, Cuvelier C, Derave W, Robinson RC, Gettemans J

(2015), Hum Mol Genet, 24(9), 2492-507

Effects of abacavir administration on structural and functional markers of platelet activation

Trevillyan JM, Arthur JF, Jing J, Andrews RK, Gardiner EE, Hoy JF

(2015), AIDS, 29(17), 2309-13

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

Su EJ, Fredriksson L, Kanzawa M, Moore S, Folestad E, Stevenson TK, Nilsson I, Sashindranath M, Schielke GP, Warnock M, Ragsdale M, Mann K, Lawrence AL, Medcalf RL, Eriksson U, Murphy GG, Lawrence DA

(2015), Front Cell Neurosci, 9, 385

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Shultz SR, Wright DK, Zheng P, Stuchbery R, Liu SJ, Sashindranath M, Medcalf RL, Johnston LA, Hovens CM, Jones NC, O'Brien TJ

(2015), Brain, 138(Pt 5), 1297-313

Evaluation of gait impairment in mice subjected to craniotomy and traumatic brain injury

Sashindranath M, Daglas M, Medcalf RL

(2015), Behav Brain Res, 286, 33-8

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets

Sánchez Guiu IM, Martínez-Martinez I, Martínez C, Navarro-Fernandez J, García-Candel F, Ferrer-Marín F, Vicente V, Watson SP, Andrews RK, Gardiner EE, Lozano ML1, Rivera J

(2015), Thromb Haemost, 114(2), 313-24

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Samson AL, Ju L, Ah Kim H, Zhang SR, Lee JA, Sturgeon SA, Sobey CG, Jackson SP, Schoenwaelder SM

(2015), Sci Rep, 5, 16171

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