Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease

Kim K, Li J, Barazia A, Tseng A, Youn SW, Abbadessa G, Yu Y, Schwartz B, Andrews RK, Gordeuk VR, Cho J

(2017), Haematologica, 102(2), 246-59

DOI: 10.3324/haematol.2016.151159

Retrospective evaluation of venous thromboembolism: are all transient provoking events the same?

Chua CC, Lim HY, Tacey M, Nandurkar H, Ho P

(2017), Eur J Haematol, 99(1), 18-26

DOI: 10.1111/ejh.12884

Class II phosphoinositide 3-kinases as novel drug targets

Falasca M, Hamilton JR, Selvadurai M, Sundaram K, Adamska A, Thompson PE

(2017), J Med Chem, 60(1), 47-65

DOI: 10.1021/acs.jmedchem.6b00963

Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells

Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld FG, Goossens S, Haigh JJ, Huylebroeck D

(2017), Stem Cells, 35(3), 611-25

DOI: 10.1002/stem.2521

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Jackson JT, Shields BJ, Shi W, Di Rago L, Metcalf D, Nicola NA, McCormack MP

(2017), Stem Cells, 35(8), 1948-57

DOI: 10.1002/stem.2648

LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage

Niego B, Broughton BRS, Ho H, Sobey CG, Medcalf RL

(2017), Fluids Barriers CNS, 14(1), 33

DOI: 10.1186/s12987-017-0081-2

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, Liddell JR, White AR

(2017), Hum Mol Genet, 26(9), 1732-46

DOI: 10.1093/hmg/ddx093

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange

Pieters, Tim; Haenebalcke, Lieven; Bruneel, Kenneth; Vandamme, Niels; Hochepied, Tino; van Hengel, Jolanda; Wirth, Dagmar; Berx, Geert; Haigh, Jody J; Van Roy, Frans; Goossens, Steven

(2017), J Vis Exp, 122,

DOI: 10.3791/55575

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Conway AJ, Brown FC, Fullinfaw RO, Kile BT, Jane SM, Curtis DJ

(2017), Dis Model Mech, 10(8), 1005-13

DOI: 10.1242/dmm.029116

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, MartÃn MT, Guillamot M, Banh RS, Xu M, Figueroa ME, Dickins RA, Abdel-Wahab O, Park CY, Tsirigos A, Neel BG, Aifantis I

(2017), Cell, 170(6), 1079-95.e20

DOI: 10.1016/j.cell.2017.07.032

Generation of an inducible mouse model to reversibly silence Stat3

Alorro MG, Pierce TP, Eissmann MF, Dijkstra C, Dickins RA, Ernst M, Buchert M, Masson F

(2017), Genesis, 55(4), e23023

DOI: 10.1002/dvg.23023

Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Dai Y, Guo J, Wang TY, Ju Y, Mitchell AJ, Bonnard T, Cui J, Richardson JJ, Hagemeyer CE, Alt K, Caruso F

(2017), Adv Healthc Mater, 6(16), 1700467

DOI: 10.1002/adhm.201700467

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening

Brazilek RJ, Tovar-Lopez FJ, Wong AKT, Tran H, Davis AS, McFadyen JD, Kaplan Z, Chunilal S, Jackson SP, Nandurkar H, Mitchell A, Nesbitt WS

(2017), Lab Chip, 17(15), 2595-608

DOI: 10.1039/c7lc00498b

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals.

Trevillyan JM, Gardiner EE, Andrews RK, Maisa A, Hearps AC, Al-Tamimi M, Crowe SM, Hoy JF

(2017), Platelets, 28(3), 301-4

DOI: 10.1080/09537104.2016.1237627

Platelet hyperreactivity in diabetes: focus on GPVI signaling-are useful drugs already available?

Arthur JF, Jandeleit-Dahm K, Andrews RK

(2017), Diabetes, 66(1), 7-13

DOI: 10.2337/db16-1098

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood SE, Richart AL, Henstridge DC, Alt K, Kiriazis H, Zammit C, Carey AL, Kammoun HL, Delbridge LM, Reddy M, Chen YC, Du XJ, Hagemeyer CE, Febbraio MA, Siebel AL, Kingwell BA

(2017), Sci Transl Med, 9(411), eaam6084

DOI: 10.1126/scitranslmed.aam6084

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy CP, Yao Y, Kammoun H, Bonnard T, Hoefer T, Alt K, Tovar-Lopez F, Rosengarten G, Ramsland PA, van der Meer AD, van den Berg A, Murphy AJ, Hagemeyer CE, Peter K, Westein E

(2017), J Thromb Haemost, 15(5), 972-82

DOI: 10.1111/jth.13666

Pharmacokinetics and safety of carfilzomib in patients with relapsed multiple myeloma and end-stage renal disease (ESRD): an open-label, single-arm, phase I study

Quach H, White D, Spencer A, Ho PJ, Bhutani D, White M, Inamdar S, Morris C, Ou Y, Gyger M

(2017), Cancer Chemother Pharmacol, 79(6), 1067-76

DOI: 10.1007/s00280-017-3287-8

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

Stone RM, Mandrekar SJ, Sanford BL, Laumann K, Geyer S, Bloomfield CD, Thiede C, Prior TW, Dàhner K, Marcucci G, Lo-Coco F, Klisovic RB, Wei A, Sierra J, Sanz MA, Brandwein JM, de Witte T, Niederwieser D, Appelbaum FR, Medeiros BC, Tallman MS, Krauter J, Schlenk RF, Ganser A, Serve H, Ehninger G, Amadori S, Larson RA, Dàhner H

(2017), N Engl J Med, 377(5), 454-64

DOI: 10.1056/NEJMoa1614359

An individualised risk-adapted protocol of pre- and post transplant zoledronic acid reduces bone loss after allogeneic stem cell transplantation: results of a phase II prospective trial

Grigg A, Butcher B, Khodr B, Bajel A, Hertzberg M, Patil S, D'Souza AB, Ganly P, Ebeling P, Wong E

(2017), Bone Marrow Transplant, 52(9), 1288-93

DOI: 10.1038/bmt.2017.108

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