Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results

Hughes TP, Leber B, Cervantes F, Spector N, Pasquini R, Clementino NCD, Schwarer AP, Dorlhiac-Llacer PE, Mahon FX, Rea D, Guerci-Bresler A, Kamel-Reid S, Bendit I, Acharya S, Glynos T, Dalal D, Branford S, Lipton JH

(2017), Leukemia, 31(11), 2529-31

DOI: 10.1038/leu.2017.247

Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury

Ziegler M, Wang X, Lim B, Leitner E, Klingberg F, Ching V, Yao Y, Huang D, Gao XM, Kiriazis H, Du XJ, Haigh JJ, Bobik A, Hagemeyer CE, Ahrens I, Peter K

(2017), Theranostics, 7(13), 3192-206

DOI: 10.7150/thno.19698

Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury

Sashindranath M, Dwyer KM, Dezfouli S, Selan C, Crikis S, Lu B, Yuan Y, Hickey MJ, Peter K, Robson SC, Cowan PJ, Nandurkar HH

(2017), Purinergic Signal, 13(2), 259-65

DOI: 10.1007/s11302-017-9558-3

Novel thrombolytic drug based on thrombin cleavable microplasminogen coupled to a single-chain antibody specific for activated GPIIb/IIIa

Bonnard T, Tennant Z, Niego B, Kanojia R, Alt K, Jagdale S, Law LS, Rigby S, Medcalf RL, Peter K, Hagemeyer CE

(2017), J Am Heart Assoc, 6(2), e004535

DOI: 10.1161/JAHA.116.004535

An evidence-based approach to myeloma bone disease

Bingham N, Reale A, Spencer A

(2017), Curr Hematol Malig Rep, 12(2), 109-18

DOI: 10.1007/s11899-017-0370-5

The incidence and natural history of dasatinib complications in the treatment of chronic myeloid leukemia

Fox LC, Cummins KD, Costello B, Yeung D, Cleary R, Forsyth C, Tatarczuch M, Burbury K, Motorna O, Shortt J, Fleming S, McQuillan A, Schwarer A, Harrup R, Holmes A, Ratnasingam S, Chan KL, Hsu WH, Ashraf A, Putt F, Grigg A

(2017), Blood Adv, 1(13), 802-11

DOI: 10.1182/bloodadvances.2016003889

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP

(2017), Sci Transl Med, 9(409), eaam5861

DOI: 10.1126/scitranslmed.aam5861

Anti-fibrinolytics

Draxler DF, Medcalf RL, Gruen RL

(2016), In: Gonzalez E, Moore HB, Moore EE (eds), Trauma Induced Coagulopathy, Springer International Publishing,

Modeling metazoan apoptotic pathways in yeast

Bloomer DT, Kitevska T, Brand IL, Jabbour AM, Nguyen H, Hawkins CJ

(2016), Methods Mol Biol, 1419,

Sprouty

Masoumi Moghaddam S, Amini A

(2016), In: Encyclopedia of Signaling Molecules, 2nd edition, Springer, USA,

Idarucizumab: an anticoagulant reversal agent for dabigatran

Brown AFT, Nandurkar H

(2016), Med Today, 17(11),

Editorial: the role of the plasminogen activating system in neurobiology

Medcalf RL, Lawrence DA

(2016), Front Cell Neurosci, 10,

Epigenetics in the biology and treatment of multiple myeloma

Spencer A, Mithraprabhu S

(2016), Eur Oncol Haematol, 12(2),

Plasminogen and stroke: more is better

Medcalf RL

(2016), J Thromb Haemost, 14(9),

Design of the randomized, Phase III, QUAZAR AML Maintenance trial of CC-486 (oral azacitidine) maintenance therapy in acute myeloid leukemia

Roboz GJ, Montesinos P, Selleslag D, Wei A, Jang JH, Falantes J, Voso MT, Sayar H, Porkka K, Marlton P, Almeida A, Mohan S, Ravandi F, Garcia-Manero G, Skikne B, Kantarjian H

(2016), Future Oncol, 12(3),

Protease-activated receptor 4: from structure to function and back again

French SL, Hamilton JR

(2016), Br J Pharmacol, 173(20),

Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

Hocking J, Mithraprabhu S, Kalff A, Spencer A

(2016), Cancer Biol Med, 13(2),

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Helsmoortel HH, De Moerloose B, Pieters T, Ghazavi F, Bresolin S, Cavé H, de Vries A, de Haas V, Flotho C, Labarque V, Niemeyer C, De Paepe P, Van Roy N, Stary J, van den Heuvel-Eibrink MM, Benoit Y, Schulte J, Goossens S, Berx G, Haigh JJ, Speleman F, Va

(2016), Haematologica, 101(6),

Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets

Ziegler M, Alt K, Paterson BM, Kanellakis P, Bobik A, Donnelly PS, Hagemeyer CE, Peter K

(2016), Sci Rep, 6,

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng Z, Pinson JA, Mountford SJ, Orive S, Schoenwaelder SM, Shackleford D, Powell A, Nelson EM, Hamilton JR, Jackson SP, Jennings IG, Thompson PE

(2016), Eur J Med Chem, 122,