Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay CS, Brown FC, Collett M, Saw J, Chiu SK, Sonderegger SE, Lucas SE, Alserihi R, Chau N, Toribio ML, McCormack MP, Chircop M, Robinson PJ, Jane SM, Curtis DJ

(2016), Leukemia, 30(10),

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Szydzik C, Niego B, Dalzell G, Knoerzer M, Ball F, Nesbitt WS, Medcalf RL, Khoshmanesh K, Mitchell A

(2016), RSC Adv, 6(91),

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains

Szabo R, Samson AL, Lawrence DA, Medcalf RL, Bugge TH

(2016), J Thromb Haemost, 14(8),

KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: results from a phase 1 study

Swords RT, Greenberg PL, Wei AH, Durrant S, Advani AS, Hertzberg MS, Lewis ID, Rivera G, Gratzinger D, Fan AC, Felsher DW, Cortes JE, Watts JM, Yarranton GT, Walling JM, Lancet JE

(2016), Leuk Res, 50,

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Scott CL, Soen B, Martens L, Skrypek N, Saelens W, Taminau J, Blancke G, Van Isterdael G, Huylebroeck D, Haigh J, Saeys Y, Guilliams M, Lambrecht BN, Berx G

(2016), J Exp Med, 213(6),

The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells

Saulep-Easton D, Vincent FB, Quah PS, Wei A, Ting SB, Croce CM, Tam C, Mackay F

(2016), Leukemia, 30(1),

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

Samson AL, Ho B, Au AE, Schoenwaelder SM, Smyth MJ, Bottomley SP, Kleifeld O, Medcalf RL

(2016), Open Biol, 6(11),

Polymer capsules for plaque-targeted in vivo delivery

Richardson JJ, Choy MY, Guo J, Liang K, Alt K, Ping Y, Cui J, Law LS, Hagemeyer CE, Caruso F

(2016), Adv Mater, 28(36),

p120 catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Pieters T, Goossens S, Haenebalcke L, Andries V, Stryjewska A, De Rycke R, Lemeire K, Hochepied T, Huylebroeck D, Berx G, Stemmler MP, Wirth D, Haigh JJ, van Hengel J, van Roy F

(2016), PLoS Genet, 12(8),

Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability

Petitjean C, Setiabakti NM, Mountford JK, Arthur JF, Ellis S, Hamilton JR

(2016), Platelets, 27(5),

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia

Pang SH, Minnich M, Gangatirkar P, Zheng Z, Ebert A, Song G, Dickins RA, Corcoran LM, Mullighan CG, Busslinger M, Huntington ND, Nutt SL, Carotta S

(2016), Leukemia, 30(6),

Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros

Ng ES, Azzola L, Bruveris FF, Calvanese V, Phipson B, Vlahos K, Hirst C, Jokubaitis VJ, Yu QC, Maksimovic J, Liebscher S, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock DN, Nilsson SK, Saffery R, Schenke-Lay

(2016), Nat Biotechnol, 34(11),

Epigenetic regulation of miRNA-124 and multiple downstream targets is associated with treatment response in myeloid malignancies

Liu H, Pattie P, Chandrasekara S, Spencer A, Dear AE

(2016), Oncol Lett, 12(3),

Ten years of cerebral venous thrombosis: male gender and myeloproliferative neoplasm is associated with thrombotic recurrence in unprovoked events

Lim HY, Ng C, Donnan G, Nandurkar H, Ho P

(2016), J Thromb Thrombolysis, 42(3),

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee WT, Cain JE, Cuddihy A, Johnson J, Dickinson A, Yeung KY, Kumar B, Johns TG, Watkins DN, Spencer A, St John JC

(2016), Cell Death Discov, 2,

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse

Larsson P, Alwis I, Niego B, Sashindranath M, Fogelstrand P, Wu MC, Glise L, Magnusson M, Daglas M, Bergh N, Jackson SP, Medcalf RL, Jern S

(2016), J Thromb Haemost, 14(12),

PTP1B deficiency enables the ability of a high-fat diet to drive the invasive character of PTEN-deficient prostate cancers

Labbé DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, Sirois J, Haigh JJ, Bégin LR, Trotman LC, Paquet M, Tremblay ML

(2016), Cancer Res, 76(11),

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurn

(2016), Nature, 538(7626),

Ablation of type-1 IFN signaling in hematopoietic cells confers protection following traumatic brain injury

Karve IP, Zhang M, Habgood M, Frugier T, Brody KM, Sashindranath M, Ek CJ, Chappaz S, Kile BT, Wright D, Wang H, Johnston L, Daglas M, Ates RC, Medcalf RL, Taylor JM, Crack PJ

(2016), eNeuro, 3(1),

GAPTrap: a simple expression system for pluripotent stem cells and their derivatives

Kao T, Labonne T, Niclis JC, Chaurasia R, Lokmic Z, Qian E, Bruveris FF, Howden SE, Motazedian A, Schiesser JV, Costa M, Sourris K, Ng E, Anderson D, Giudice A, Farlie P, Cheung M, Lamande SR, Penington AJ, Parish CL, Thomson LH, Rafii A, Elliott DA, Elef

(2016), Stem Cell Rep, 7(3),

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