Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Heavy menstrual bleeding and dysmenorrhea are improved by magentic resonance guided focused ultrasound surgery (MRgFUS) of adenomyosis

Jayaram R, Subbarayan K, Mithraprabhu S, Govindarajan M

(2016), Fertil Res Pract, 2,

Retrospective review on isolated distal deep vein thrombosis (IDDVT) - a benign entity or not?

Ho P, Lim HY, Chua CC, Sleeman M, Tacey M, Donnan G, Nandurkar H

(2016), Thromb Res, 142,

Molecular imaging of activated platelets allows the detection of pulmonary embolism with magnetic resonance imaging

Heidt T, Ehrismann S, HÖvener JB, Neudorfer I, Hilgendorf I, Reisert M, Hagemeyer CE, Zirlik A, ReinÖhl J, Bode C, Peter K, von Elverfeldt D, von Zur Muhlen C

(2016), Sci Rep, 6,

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Guirguis AA, Slape CI, Failla LM, Saw J, Tremblay CS, Powell DR, Rossello F, Wei A, Strasser A, Curtis DJ

(2016), Cell Death Differ, 23(6),

Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia

Ghisi M, Kats L, Masson F, Li J, Kratina T, Vidacs E, Gilan O, Doyle MA, Newbold A, Bolden JE, Fairfax KA, de Graaf CA, Firth M, Zuber J, Dickins RA, Corcoran LM, Dawson MA, Belz GT, Johnstone RW

(2016), Cancer Cell, 30(1),

Platelet and erythrocyte sources of s1p are redundant for vascular development and homeostasis, but both rendered essential after plasma s1p depletion in anaphylactic shock

Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E

(2016), Circ Res, 119(8),

Humanizing the protease-activated receptor (par) expression profile in mouse platelets by knocking par1 into the par3 locus reveals par1 expression is not tolerated in mouse platelets

French SL, Paramitha AC, Moon MJ, Dickins RA, Hamilton JR

(2016), PLoS One, 11(10),

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French SL, Arthur JF, Lee H, Nesbitt WS, Andrews RK, Gardiner EE, Hamilton JR

(2016), J Thromb Haemost, 14(8),

A-Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets

Facey A, Pinar I, Arthur JF, Qiao J, Jing J, Mado B, Carberry J, Andrews RK, Gardiner EE

(2016), Biochemistry, 55(8),

Targeting p38 or MK2 enhances the anti-leukemic activity of Smac-mimetics

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M,

(2016), Cancer Cell, 29(2),

Profiling clinical platelet and plasma use to inform blood supply and contingency planning: PUPPY, the prospective utilization of platelets and plasma study

Fedele PL, Polizzotto MN, Grigoriadis G, Waters N, Comande M, Borosak M, Portbury D, Wood EM

(2016), Transfusion, 56(10),

Multicentre randomised placebo-controlled trial of oral anticoagulation with apixaban in systemic sclerosis-related pulmonary arterial hypertension: the SPHInX study protocol

Calderone A, Stevens W, Prior D, Nandurkar H, Gabbay E, Proudman SM, Williams T, Celermajer D, Sahhar J, Wong PK, Thakkar V, Dwyer N, Wrobel J, Chin W, Liew D, Staples M, Buchbinder R, Nikpour M

(2016), BMJ Open, 6(12),

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J

(2016), Sci Transl Med, 8(339),

Isavuconazole as salvage therapy for mucormycosis

Graves R, Morrissey CO, Wei A, Coutsouvelis J, Ellis S, Pham A, Gooi J, Ananda-Rajah M

(2016), Med Mycol Case Rep, 11,

Primary antifungal prophylaxis in adult patients with acute lymphoblastic leukaemia: a multicentre audit

Doan TN, Kirkpatrick CMJ, Walker P, Slavin M, Ananda-Rajah M, Morissey CO, Urbancic K, Grigg A, Spencer A, Szer J, Seymour J, Kong DCM

(2016), J Antimicrob Chemother, 71(2),

Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma

Seggewiss-Bernhardt R, Bargou RC, Goh YT, Stewart AK, Spencer A, Alegre A, Bladé J, Ottmann OG, Fernandez-Ibarra C, Lu H, Pain S, Akimov M, Iyer SP

(2015), Cancer, 121(13), 2185-92

The residual risk of transfusion-transmitted cytomegalovirus infection associated with leucodepleted blood components

Seed CR, Wong J, Polizzotto MN, Faddy H, Keller AJ, Pink J

(2015), Vox Sang, 109(1), 11-7

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D

(2015), Proc Natl Acad Sci USA, 112(5), 1535-40

A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia

Kipps TJ, Eradat H, Grosicki S, Catalano J, Cosolo W, Dyagil IS, Yalamanchili S, Chai A, Sahasranaman S, Punnoose E, Hurst D, Pylypenko H

(2015), Leuk Lymphoma, 56(10), 2826-33

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

Dimopoulos MA, Weisel KC, Song KW, Delforge M, Karlin L, Goldschmidt H, Moreau P, Banos A, Oriol A, Garderet L, Cavo M, Ivanova V, Alegre A, Martinez-Lopez J, Chen C, Spencer A, Knop S, Bahlis NJ, Renner C, Yu X, Hong K, Sternas L, Jacques C, Zaki MH, San Miguel JF

(2015), Haematologica, 100(10), 1327-33