Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

Manchev VT, Hilpert M, Berrou E, Elaib Z, Aouba A, Boukour S, Souquere S, Pierron G, Rameau P, Andrews R, Lanza F, Bobe R, Vainchenker W, Rosa JP, Bryckaert M, Debili N, Favier R, Raslova H

(2014), Blood, 124(16), 2554-63

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

Luo L, Wall AA, Yeo JC, Condon ND, Norwood SJ, Schoenwaelder S, Chen KW, Jackson S, Jenkins BJ, Hartland EL, Schroder K, Collins BM, Sweet MJ, Stow JL

(2014), Nat Commun, 5, 4407

Mechanisms and potential molecular markers of early response to combination epigenetic therapy in patients with myeloid malignancies

Liu HB, Urbanavicius D, Tan P, Spencer A, Dear AE

(2014), Int J Oncol, 45(4), 1742-8

Incidence of venous thromboembolism in different ethnic groups: a regional direct comparison study

Liao S, Woulfe T, Hyder S, Merriman E, Simpson D, Chunilal S

(2014), J Thromb Haemost, 12(2), 214-9

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner E, Ho Tin Noe B, Vainchenker W, Villeval JL, Jandrot-Perrus M

(2014), Blood, 124(7), 1136-45

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice

Hughan SC, Spring CM, Schoenwaelder SM, Sturgeon S, Alwis I, Yuan Y, McFadyen JD, Westein E, Goddard D, Ono A, Yamanashi Y, Nesbitt WS, Jackson SP

(2014), J Biol Chem, 289(8), 5051-60

The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression

Huard CC, Tremblay CS, Magron A, Lévesque G, Carreau M

(2014), Proc Natl Acad Sci USA, 111(6), 2152-7

Controlling pre-leukemic thymocyte self-renewal

Goossens S, Van Vlierberghe P

(2014), PLoS Genet, 10(12), e1004881

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

Gitz E, Pollitt AY, Gitz-Francois JJ, Alshehri O, Mori J, Montague S, Nash GB, Douglas MR, Gardiner EE, Andrews RK, Buckley CD, Harrison P, Watson SP

(2014), Blood, 124(14), 2262-70

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

Farhang Ghahremani M, Radaelli E, Haigh K, Bartunkova S, Haenebalcke L, Marine JC, Goossens S, Haigh JJ

(2014), Cell Cycle, 13(9), 1501-7

NF-ΚB control of T cell development

Gerondakis S, Fulford TS, Messina NL, Grumont RJ

(2014), Nat Immunol, 15(1), 15-25

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells

Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang T

(2014), PLoS Genet, 10(12), e1004768

Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?

Gardiner EE, Medcalf RL

(2014), J Thromb Haemost, 12(10), 1703-5

DiagnoSTic assays for heparin-induced thrombocytopenia

Gardiner EE, Andrews RK, Cuker A

(2014), Br J Haematol, 166(5), 631-3

Structure and function of platelet receptors initiating blood clotting

Gardiner EE, Andrews RK

(2014), Adv Exp Med Biol, 844, 263-75

Platelet receptor expression and shedding: glycoprotein Ib-IX-V and glycoprotein VI

Gardiner EE, Andrews RK

(2014), Transfus Med Rev, 28(2), 56-60

Plasma sGPVI: Changing levels in human disease

Gardiner EE, Andrews RK

(2014), Thromb Res, 133(3), 306-7

t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions

Freeman R, Niego B, Croucher DR, Pedersen LO, Medcalf RL

(2014), Brain Res, 1565, 63-73

Health economic impact of high-dose versus standard-dose cytarabine induction chemotherapy for acute myeloid leukaemia

Fedele PL, Avery S, Patil S, Spencer A, Haas M, Wei A

(2014), Intern Med J, 44(8), 757-63

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

Denecker G, Vandamme N, Akay O, Koludrovic D, Taminau J, Lemeire K, Gheldof A, De Craene B, Van Gele M, Brochez L, Udupi GM, Rafferty M, Balint B, Gallagher WM, Ghanem G, Huylebroeck D, Haigh J, van den Oord J, Larue L, Davidson I, Marine JC, Berx G

(2014), Cell Death Differ, 21(8), 1250-61

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