Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

Slape CI, Saw J, Jowett JB, Aplan PD, Strasser A, Jane SM, Curtis DJ

(2012), Blood, 120(12), 2475-83

Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function

Schoenwaelder SM, Jackson SP

(2012), Blood, 119(5), 1320-1

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

Sashindranath M, Sales E, Daglas M, Freeman R, Samson AL, Cops EJ, Beckham S, Galle A, McLean C, Morganti-Kossmann C, Rosenfeld JV, Madani R, Vassalli JD, Su EJ, Lawrence DA, Medcalf RL

(2012), Brain, 135(Pt 11), 3251-64

Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death

Sandow JJ, Jabbour AM, Condina MR, Daunt CP, Stomski FC, Green BD, Riffkin CD, Hoffmann P, Guthridge MA, Silke J, Lopez AF, Ekert PG

(2012), Cell Death Differ, 19(4), 633-41

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin

Samson AL, Knaupp AS, Sashindranath M, Borg RJ, Au AE, Cops EJ, Saunders HM, Cody SH, McLean CA, Nowell CJ, Hughes VA, Bottomley SP, Medcalf RL

(2012), Cell Rep, 2(4), 889-901

The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms

Nourse JP, Lea R, Crooks P, Wright G, Tran H, Catalano J, Brighton T, Grigg A, Marlton P, Gandhi MK

(2012), Blood Coagul Fibrinolysis, 23(1), 45-50

t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

Niego B, Freeman R, Puschmann TB, Turnley AM, Medcalf RL

(2012), Blood, 119(20), 4752-61

Wnt1 is anti-lymphangiogenic in a melanoma mouse model

Niederleithner H, Heinz M, Tauber S, Bilban M, Pehamberger H, Sonderegger S, Knöfler M, Bracher A, Berger W, Loewe R, Petzelbauer P

(2012), J Invest Dermatol, 132(9), 2235-44

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

Nesbitt WS, Harper IS, Schoenwaelder SM, Yuan Y, Jackson SP

(2012), Methods Mol Biol, 788, 73-89

Plasminogen activation and thrombolysis for ischemic stroke

Medcalf RL, Davis SM

(2012), Int J Stroke, 7(5), 419-25

Desmoteplase: discovery, insights and opportunities for ischaemic stroke

Medcalf RL

(2012), Br J Pharmacol, 165(1), 75-89

Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period

McLintock C, Brighton T, Chunilal S, Dekker G, McDonnell N, McRae S, Muller P, Tran H, Walters BN, Young L; Councils of the Society of Obstetric Medicine of Australia and New Zealand; Australasian Society of Thrombosis and Haemostasis

(2012), Aust N Z J Obstet Gynaecol, 52(1), 14-22

The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions

Lee H, Sturgeon SA, Jackson SP, Hamilton JR

(2012), Thromb Haemost, 107(2), 328-37

Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice

Lee H, Sturgeon SA, Mountford JK, Jackson SP, Hamilton JR

(2012), Br J Pharmacol, 166(7), 2188-97

Physiology, pharmacology, and therapeutic potential of protease-activated receptors in vascular disease

Lee H, Hamilton JR

(2012), Pharmacol Ther, 134(2), 246-59

Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression

Larsson P, Ulfhammer E, Magnusson M, Bergh N, Lunke S, El-Osta A, Medcalf RL, Svensson PA, Karlsson L, Jern S

(2012), PLoS One, 7(2), e31573

Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood

Jung SM, Moroi M, Soejima K, Nakagaki T, Miura Y, Berndt MC, Gardiner EE, Howes JM, Pugh N, Bihan D, Watson SP, Farndale RW

(2012), J Biol Chem, 287(35), 30000-13

Serum protein electrophoresis: a precautionary tale

Grigoriadis G, Shortt J, Quach H, Opat S

(2012), Pathology, 44(4), 371-3

Correct diagnosis of NK and T cell lymphomas

Gregory G, Fong CY, Whitehead S, Grigoriadis G

(2012), Pathology, 44(4), 383-4

The NET effect of clot formation

Gardiner EE, Ward CM, Andrews RK

(2012), J Thromb Haemost, 10(1), 133-5

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